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dc.contributor.authorSilov, Serhii-
dc.contributor.authorZaburannyi, Nestor-
dc.contributor.authorAnisimova, Maria-
dc.contributor.authorOstash, Bohdan-
dc.date.accessioned2021-01-14T10:56:26Z-
dc.date.available2021-01-14T10:56:26Z-
dc.date.issued2020-
dc.identifier.issn0046-8991de_CH
dc.identifier.issn0973-7715de_CH
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810805/de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/21303-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractStreptomycetes, Gram-positive bacteria with huge and GC-rich genomes provide an ample example of codon usage bias taken to the extreme. Particularly, in all sequenced to date streptomycete genomes leucyl codon TTA is the rarest one. It is present (usually once or twice) in 70–200 out of 7000–8000 coding sequences that make up a typical streptomycete genome. tRNALeu UAA of streptomycetes, encoded by the bldA gene, has been shown to be present in mature form only after the onset of morphological differentiation and activation of secondary metabolism. Consequently, during the early stages of cell growth, the translation of genes carrying the TTA codon can be interrupted due to the absence of tRNALeu UAA. Several reports show that mutations of TTA to synonymous codons in certain genes indeed relieve their expression from bldA dependence. However, the deletion of bldA does not always arrest the expression of TTA-containing genes. The nucleotides T/C downstream of TTA were suggested, in 2002, to favor TTA mistranslation. We tested this hypothesis using sizable datasets derived from individual Streptomyces genome and a subset of TTA? genes for secondary metabolism known for their active expression. Our results revealed nucleotide biases downstream of NNA codons family, such as the preference for C and the avoidance of A. Yet, none of the observed biases was sufficient to claim a special case for TTA codon. Hence, the issue of codon context and TTA codon mistranslation in Streptomyces deserves further elaboration.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofIndian Journal of Microbiologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBldA-regulationde_CH
dc.subjectStreptomycesde_CH
dc.subjectUUA codonde_CH
dc.subjectMorphological differentiationde_CH
dc.subject.ddc572: Biochemiede_CH
dc.subject.ddc579: Mikrobiologiede_CH
dc.titleThe use of the rare TTA codon in Streptomyces genes : significance of the codon context?de_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1007/s12088-020-00902-6de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end30de_CH
zhaw.pages.start24de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume61de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.funding.snf182330de_CH
zhaw.webfeedComputational Genomicsde_CH
zhaw.funding.zhawThe effect of programmed ribosomal frameshifting on codon usage biasde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Silov, S., Zaburannyi, N., Anisimova, M., & Ostash, B. (2020). The use of the rare TTA codon in Streptomyces genes : significance of the codon context? Indian Journal of Microbiology, 61(1), 24–30. https://doi.org/10.1007/s12088-020-00902-6
Silov, S. et al. (2020) ‘The use of the rare TTA codon in Streptomyces genes : significance of the codon context?’, Indian Journal of Microbiology, 61(1), pp. 24–30. Available at: https://doi.org/10.1007/s12088-020-00902-6.
S. Silov, N. Zaburannyi, M. Anisimova, and B. Ostash, “The use of the rare TTA codon in Streptomyces genes : significance of the codon context?,” Indian Journal of Microbiology, vol. 61, no. 1, pp. 24–30, 2020, doi: 10.1007/s12088-020-00902-6.
SILOV, Serhii, Nestor ZABURANNYI, Maria ANISIMOVA und Bohdan OSTASH, 2020. The use of the rare TTA codon in Streptomyces genes : significance of the codon context? Indian Journal of Microbiology [online]. 2020. Bd. 61, Nr. 1, S. 24–30. DOI 10.1007/s12088-020-00902-6. Verfügbar unter: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810805/
Silov, Serhii, Nestor Zaburannyi, Maria Anisimova, and Bohdan Ostash. 2020. “The Use of the Rare TTA Codon in Streptomyces Genes : Significance of the Codon Context?” Indian Journal of Microbiology 61 (1): 24–30. https://doi.org/10.1007/s12088-020-00902-6.
Silov, Serhii, et al. “The Use of the Rare TTA Codon in Streptomyces Genes : Significance of the Codon Context?” Indian Journal of Microbiology, vol. 61, no. 1, 2020, pp. 24–30, https://doi.org/10.1007/s12088-020-00902-6.


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