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dc.contributor.authorPalazón, Javier-
dc.contributor.authorMallol, Anna-
dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorLettenbauer, Christine-
dc.contributor.authorCusidó, Rosa M.-
dc.contributor.authorPiñol, M. Teresa-
dc.date.accessioned2018-01-17T12:19:45Z-
dc.date.available2018-01-17T12:19:45Z-
dc.date.issued2003-
dc.identifier.issn0032-0943de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2094-
dc.description.abstractWe tested the effect of three variables: the bioreactor system (Wave or Spray reactor), medium exchange and culture period, on the capacity of a selected hairy root line of Panax ginseng to produce ginsenosides. Among the reactors, the Wave bioreactor appeared to be the most efficient in promoting hairy root line growth. Periodic exchanges of the medium and a longer culture period increased the growth rate of cultured hairy root line and, consequently, its capacity to produce ginsenosides. Under established optimum conditions (medium exchange every 14 days over a culture period of 56 days using the Wave bioreactor), the initial root fresh weight was enhanced more than 28-fold, giving a root biomass of 284.9 g L(-1) and a ginsenoside content of 145.6 mg L(-1). It is noteworthy that this ginsenoside production exceeded by almost 3-fold that obtained during the shake flask culture of our hairy root line, although it often happens that the scale-up from shake flask to a bioreactor culture results in reduced productivities. To our knowledge this is the first time that a Wave bioreactor has been used for hairy root culture.de_CH
dc.language.isoende_CH
dc.publisherThiemede_CH
dc.relation.ispartofPlanta Medicade_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleGrowth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactorde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
dc.identifier.doi10.1055/s-2003-38873de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end349de_CH
zhaw.pages.start344de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume69de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Palazón, J., Mallol, A., Eibl-Schindler, R., Lettenbauer, C., Cusidó, R. M., & Piñol, M. T. (2003). Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor. Planta Medica, 69(4), 344–349. https://doi.org/10.1055/s-2003-38873
Palazón, J. et al. (2003) ‘Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor’, Planta Medica, 69(4), pp. 344–349. Available at: https://doi.org/10.1055/s-2003-38873.
J. Palazón, A. Mallol, R. Eibl-Schindler, C. Lettenbauer, R. M. Cusidó, and M. T. Piñol, “Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor,” Planta Medica, vol. 69, no. 4, pp. 344–349, 2003, doi: 10.1055/s-2003-38873.
PALAZÓN, Javier, Anna MALLOL, Regine EIBL-SCHINDLER, Christine LETTENBAUER, Rosa M. CUSIDÓ und M. Teresa PIÑOL, 2003. Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor. Planta Medica. 2003. Bd. 69, Nr. 4, S. 344–349. DOI 10.1055/s-2003-38873
Palazón, Javier, Anna Mallol, Regine Eibl-Schindler, Christine Lettenbauer, Rosa M. Cusidó, and M. Teresa Piñol. 2003. “Growth and Ginsenoside Production in Hairy Root Cultures of Panax Ginseng Using a Novel Bioreactor.” Planta Medica 69 (4): 344–49. https://doi.org/10.1055/s-2003-38873.
Palazón, Javier, et al. “Growth and Ginsenoside Production in Hairy Root Cultures of Panax Ginseng Using a Novel Bioreactor.” Planta Medica, vol. 69, no. 4, 2003, pp. 344–49, https://doi.org/10.1055/s-2003-38873.


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