Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis

Pehlic, Vildana; Volken, Thomas; Holbro, Andreas; Jirout, Zuzana; Drexler, Beatrice; Buser, Andreas; Infanti, Laura

doi:10.1159/000509026

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-20351

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis
Authors:	Pehlic, Vildana Volken, Thomas Holbro, Andreas Jirout, Zuzana Drexler, Beatrice Buser, Andreas Infanti, Laura
et. al:	No
DOI:	10.1159/000509026 10.21256/zhaw-20351
Published in:	Transfusion Medicine and Hemotherapy
Volume(Issue):	48
Issue:	2
Page(s):	71
Pages to:	78
Issue Date:	5-Aug-2020
Publisher / Ed. Institution:	Karger
ISSN:	1660-3796 1660-3818
Language:	English
Subjects:	High-frequency donors; Interdonation interval; Ferritin; Haemoglobin
Subject (DDC):	610: Medicine and health
Abstract:	Background: High-intensity donation is a risk factor for iron deficiency in blood donors. Interdonation intervals for whole blood (WB) donation and double unit red blood cell apheresis (2RBC) vary among countries. We retrospectively evaluated the course of haemoglobin (Hb) and ferritin values in men regularly donating WB 4 times a year or 2RBC twice a year (i.e., maximal frequency) over a period of 48 months. Methods: Data of male donors with 16 WB or 8 2RBC consecutive donations were analysed. The minimum Hb levels for WB donation and 2RBC apheresis (collection of 360 mL RBC) were 135 and 140 g/L, respectively. There was no lower limit set for ferritin, and no iron was substituted. Results: We identified 294 WB (mean age 53 years, SD 11) and 151 2RBC donors (mean age 48 years, SD 9) who donated at a mean interval of 97 (SD 18) and 201 days (SD 32), respectively, between January 1, 2008, and December 31, 2013. At baseline, Hb and ferritin values were lower in WB donors compared to 2RBC donors, with a mean Hb of 153 g/L (SD 13) versus 159 g/L (SD 8) and a mean ferritin of 44 μg/L (SD 52) versus 73 μg/L (SD 56; p < 0.001 for both parameters), respectively. Ferritin was below 15 μg/L in 40 WB (14%) and in 4 (3%) 2RBC donors. In WB donors, the mean Hb levels at baseline versus last donation showed no significant difference (153 vs. 152g/L, p = 0.068), whereas the mean ferritin levels decreased significantly (44 vs. 35 μg/L, p < 0.001). The 2RBC donor group displayed a statistically different decrease in both the mean Hb levels (158 vs. 157 g/L; p < 0.05) and the mean ferritin levels (73 vs. 66 μg/L; p = 0.052). The lowest Hb was measured at the 11th WB donation (152 g/L; p < 0.05) and at the 4th 2RBC apheresis (157 g/L; p < 0.05). There was no deferral due to low Hb at any time. The lowest ferritin was shown at the 4th WB (37 μg/L) and at the 3rd 2RBC donation (60 μg/L), respectively. At the last visit, ferritin was below 15 μg/L in 23 WB donors (8%) and in 2 2RBC donors (1%). Conclusions: High-intensity male donors with an interdonation interval of 12 weeks for WB donation and 24 weeks for 2RBC apheresis maintain acceptable Hb levels and, after an initial decline,stable ferritin levels despite ongoing blood donation.
URI:	https://digitalcollection.zhaw.ch/handle/11475/20351
Fulltext version:	Published version
License (according to publishing contract):	CC BY-NC 4.0: Attribution - Non commercial 4.0 International
Departement:	School of Health Sciences
Organisational Unit:	Institute of Public Health (IPH)
Appears in collections:	Publikationen Gesundheit

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Pehlic, V., Volken, T., Holbro, A., Jirout, Z., Drexler, B., Buser, A., & Infanti, L. (2020). Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis. Transfusion Medicine and Hemotherapy, 48(2), 71–78. https://doi.org/10.1159/000509026

Pehlic, V. et al. (2020) ‘Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis’, Transfusion Medicine and Hemotherapy, 48(2), pp. 71–78. Available at: https://doi.org/10.1159/000509026.

V. Pehlic et al., “Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis,” Transfusion Medicine and Hemotherapy, vol. 48, no. 2, pp. 71–78, Aug. 2020, doi: 10.1159/000509026.

PEHLIC, Vildana, Thomas VOLKEN, Andreas HOLBRO, Zuzana JIROUT, Beatrice DREXLER, Andreas BUSER und Laura INFANTI, 2020. Long-term course of haemoglobin and ferritin values in high-frequency donors of whole blood and double erythrocyte apheresis. Transfusion Medicine and Hemotherapy. 5 August 2020. Bd. 48, Nr. 2, S. 71–78. DOI 10.1159/000509026

Pehlic, Vildana, Thomas Volken, Andreas Holbro, Zuzana Jirout, Beatrice Drexler, Andreas Buser, and Laura Infanti. 2020. “Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis.” Transfusion Medicine and Hemotherapy 48 (2): 71–78. https://doi.org/10.1159/000509026.

Pehlic, Vildana, et al. “Long-Term Course of Haemoglobin and Ferritin Values in High-Frequency Donors of Whole Blood and Double Erythrocyte Apheresis.” Transfusion Medicine and Hemotherapy, vol. 48, no. 2, Aug. 2020, pp. 71–78, https://doi.org/10.1159/000509026.