Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-20321
Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | How much synthetic oxytocin is infused during labour? : a review and analysis of regimens used in 12 countries |
Authors: | Daly, Deirdre Minnie, Karin C. S. Blignaut, Alwiena Blix, Ellen Vika Nilsen, Anne Britt Dencker, Anna Beeckman, Katrien Gross, Mechthild Maria Pehlke-Milde, Jessica Grylka, Susanne Koenig-Bachmann, Martina Clausen, Jette Aaroe Hadjigeorgiou, Eleni Morano, Sandra Iannuzzi, Laura Baranowska, Barbara Kiersnowska, Iwona Uvnäs-Moberg, Kerstin |
et. al: | No |
DOI: | 10.1371/journal.pone.0227941 10.21256/zhaw-20321 |
Published in: | PLOS ONE |
Volume(Issue): | 15 |
Issue: | 7 |
Page(s): | e0227941 |
Issue Date: | 28-Jul-2020 |
Publisher / Ed. Institution: | Public Library of Science |
ISSN: | 1932-6203 |
Language: | English |
Subject (DDC): | 618.4: Childbirth |
Abstract: | Objective: To compare synthetic oxytocin infusion regimens used during labour, calculate the International Units (IU) escalation rate and total amount of IU infused over eight hours. Design: Observational study. Setting: Twelve countries, eleven European and South Africa. Sample: National, regional or institutional-level regimens on oxytocin for induction and augmentation labour. Methods: Data on oxytocin IU dose, infusion fluid amount, start dose, escalation rate and maximum dose were collected. Values for each regimen were converted to IU in 1000ml diluent. One IU corresponded to 1.67μg for doses provided in grams/micrograms. IU hourly dose increase rates were based on escalation frequency. Cumulative doses and total IU amount infused were calculated by adding the dose administered for each previous hour. Main Outcome Measures Oxytocin IU dose infused. Results: Data were obtained on 21 regimens used in 12 countries. Details on the start dose, escalation interval, escalation rate and maximum dose infused were available from 16 regimens. Starting rates varied from 0.06 IU/hour to 0.90 IU/hour, and the maximum dose rate varied from 0.90 IU/hour to 3.60 IU/hour. The total amount of IU oxytocin infused, estimated over eight hours, ranged from 2.38 IU to 27.00 IU, a variation of 24.62 IU and an 11-fold difference. Conclusion: Current variations in oxytocin regimens for induction and augmentation of labour are inexplicable. It is crucial that the appropriate minimum infusion regimen is administered because synthetic oxytocin is a potentially harmful medication with serious consequences for women and babies when inappropriately used. Estimating the total amount of oxytocin IU received by labouring women, alongside the institution’s mode of birth and neonatal outcomes, may deepen our understanding and be the way forward to identifying the optimal infusion regimen. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/20321 |
Fulltext version: | Published version |
License (according to publishing contract): | CC BY 4.0: Attribution 4.0 International |
Departement: | School of Health Sciences |
Organisational Unit: | Institute of Midwifery and Reproductive Health (IHG) |
Appears in collections: | Publikationen Gesundheit |
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File | Description | Size | Format | |
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2020_Daly_etal_Synthetic-oxytocin_PLOS-ONE.pdf | 1.09 MB | Adobe PDF | View/Open |
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Daly, D., Minnie, K. C. S., Blignaut, A., Blix, E., Vika Nilsen, A. B., Dencker, A., Beeckman, K., Gross, M. M., Pehlke-Milde, J., Grylka, S., Koenig-Bachmann, M., Clausen, J. A., Hadjigeorgiou, E., Morano, S., Iannuzzi, L., Baranowska, B., Kiersnowska, I., & Uvnäs-Moberg, K. (2020). How much synthetic oxytocin is infused during labour? : a review and analysis of regimens used in 12 countries. Plos One, 15(7), e0227941. https://doi.org/10.1371/journal.pone.0227941
Daly, D. et al. (2020) ‘How much synthetic oxytocin is infused during labour? : a review and analysis of regimens used in 12 countries’, PLOS ONE, 15(7), p. e0227941. Available at: https://doi.org/10.1371/journal.pone.0227941.
D. Daly et al., “How much synthetic oxytocin is infused during labour? : a review and analysis of regimens used in 12 countries,” PLOS ONE, vol. 15, no. 7, p. e0227941, Jul. 2020, doi: 10.1371/journal.pone.0227941.
DALY, Deirdre, Karin C. S. MINNIE, Alwiena BLIGNAUT, Ellen BLIX, Anne Britt VIKA NILSEN, Anna DENCKER, Katrien BEECKMAN, Mechthild Maria GROSS, Jessica PEHLKE-MILDE, Susanne GRYLKA, Martina KOENIG-BACHMANN, Jette Aaroe CLAUSEN, Eleni HADJIGEORGIOU, Sandra MORANO, Laura IANNUZZI, Barbara BARANOWSKA, Iwona KIERSNOWSKA und Kerstin UVNÄS-MOBERG, 2020. How much synthetic oxytocin is infused during labour? : a review and analysis of regimens used in 12 countries. PLOS ONE. 28 Juli 2020. Bd. 15, Nr. 7, S. e0227941. DOI 10.1371/journal.pone.0227941
Daly, Deirdre, Karin C. S. Minnie, Alwiena Blignaut, Ellen Blix, Anne Britt Vika Nilsen, Anna Dencker, Katrien Beeckman, et al. 2020. “How Much Synthetic Oxytocin Is Infused during Labour? : A Review and Analysis of Regimens Used in 12 Countries.” Plos One 15 (7): e0227941. https://doi.org/10.1371/journal.pone.0227941.
Daly, Deirdre, et al. “How Much Synthetic Oxytocin Is Infused during Labour? : A Review and Analysis of Regimens Used in 12 Countries.” Plos One, vol. 15, no. 7, July 2020, p. e0227941, https://doi.org/10.1371/journal.pone.0227941.
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