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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-3479
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dc.contributor.authorMeier, Nadja-
dc.contributor.authorMeier, Beat-
dc.contributor.authorPeter, Samuel-
dc.contributor.authorWolfram, Evelyn-
dc.date.accessioned2018-01-10T13:08:46Z-
dc.date.available2018-01-10T13:08:46Z-
dc.date.issued2017-10-27-
dc.identifier.issn1420-3049de_CH
dc.identifier.issn1433-1373de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/1970-
dc.description.abstractFor the European Pharmacopoeia (Ph. Eur.) herbal monograph draft of Cassia angustifolia Vahl. and Cassia senna L. leaves and pods, a safety limitation of aloe-emodin and rhein was proposed, due to toxicological concerns. A quantitative, analytical method of the anthraquinone aglycones in all Ph. Eur. monographed herbal laxatives is of interest. A rational method development for the aglycones aloe-emodin, rhein, emodin, chrysophanol, and physcion in five herbal drugs was realized by using 3D chromatographic modelling (temperature, solvent, and gradient time) and design of experiment (DOE) software (DryLab® 4). A methodical approach suitable for the challenging peak tracking in the chromatograms of the herbal drugs in dependence on the changes in the chromatographic conditions is described by using a combination of mass spectroscopy (MS) data (UHPLC-QDa), UV/Vis-spectra, and peak areas. The model results indicate a low robust range and showed that with the selected chromatographic system, small interferences could not be averted. The separation achieved shows a pure UV/Vis spectrum for all aglycones except for chrysophanol in Aloe barbadensis and emodin in Cassia angustifolia fruit. A gradient with the best resolution of the aglycones in all five drugs is proposed, and its suitability demonstrated for the quantification of aglycones in these herbal drugs.de_CH
dc.language.isoende_CH
dc.publisherMDPIde_CH
dc.relation.ispartofMoleculesde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectAloe-emodinde_CH
dc.subjectAnthraquinone aglyconesde_CH
dc.subjectChromatographic modellingde_CH
dc.subjectChrysophanolde_CH
dc.subjectDesign of experiment (DOE)de_CH
dc.subjectEmodinde_CH
dc.subjectHerbal laxativesde_CH
dc.subjectPhyscionde_CH
dc.subjectRheinde_CH
dc.subjectUltra high performance liquid chromatography (UHPLC)de_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleIn-Silico UHPLC method optimization for aglycones in the herbal laxatives aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Rootsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.21256/zhaw-3479-
dc.identifier.doi10.3390/molecules22111838de_CH
dc.identifier.pmid29076992de_CH
zhaw.funding.euNode_CH
zhaw.issue11de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume22de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPhytopharmaziede_CH
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Meier, N., Meier, B., Peter, S., & Wolfram, E. (2017). In-Silico UHPLC method optimization for aglycones in the herbal laxatives aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots. Molecules, 22(11). https://doi.org/10.21256/zhaw-3479
Meier, N. et al. (2017) ‘In-Silico UHPLC method optimization for aglycones in the herbal laxatives aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots’, Molecules, 22(11). Available at: https://doi.org/10.21256/zhaw-3479.
N. Meier, B. Meier, S. Peter, and E. Wolfram, “In-Silico UHPLC method optimization for aglycones in the herbal laxatives aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots,” Molecules, vol. 22, no. 11, Oct. 2017, doi: 10.21256/zhaw-3479.
MEIER, Nadja, Beat MEIER, Samuel PETER und Evelyn WOLFRAM, 2017. In-Silico UHPLC method optimization for aglycones in the herbal laxatives aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots. Molecules. 27 Oktober 2017. Bd. 22, Nr. 11. DOI 10.21256/zhaw-3479
Meier, Nadja, Beat Meier, Samuel Peter, and Evelyn Wolfram. 2017. “In-Silico UHPLC Method Optimization for Aglycones in the Herbal Laxatives Aloe Barbadensis Mill., Cassia Angustifolia Vahl Pods, Rhamnus Frangula L. Bark, Rhamnus Purshianus DC. Bark, and Rheum Palmatum L. Roots.” Molecules 22 (11). https://doi.org/10.21256/zhaw-3479.
Meier, Nadja, et al. “In-Silico UHPLC Method Optimization for Aglycones in the Herbal Laxatives Aloe Barbadensis Mill., Cassia Angustifolia Vahl Pods, Rhamnus Frangula L. Bark, Rhamnus Purshianus DC. Bark, and Rheum Palmatum L. Roots.” Molecules, vol. 22, no. 11, Oct. 2017, https://doi.org/10.21256/zhaw-3479.


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