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dc.contributor.authorJossen, Valentin-
dc.contributor.authorEibl-Schindler, Regine-
dc.contributor.authorPörtner, Ralf-
dc.contributor.authorKraume, Matthias-
dc.contributor.authorEibl, Dieter-
dc.date.accessioned2020-03-05T14:05:34Z-
dc.date.available2020-03-05T14:05:34Z-
dc.date.issued2017-
dc.identifier.isbn9780444636638de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/19652-
dc.description.abstractIt is undisputed that stirred bioreactors are the most common type of bioreactors for submerged bioprocesses. Stirred bioreactors for biopharmaceuticals, which represent the strongest-growing branch of modern biotechnological products, are the focus of our chapter. They are available in working volumes from milliliters up to 70 m3 and are used for a wide range of expression systems that require aseptic conditions. Based on a brief summary of some basic rules for the construction and operation of stirred bioreactors, this chapter will review key engineering issues that affect the design of aseptic stirred bioreactors. We will also provide readers with some general information on transport phenomena in stirred bioreactors before discussing special design aspects and performance parameters for expression systems (mammalian and microbial cells) that prevail in commercial biopharmaceutical production processes. Special attention will be paid to single-use stirred bioreactors, which may have advantages over their reusable counterparts and have become widely accepted over the past years.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofCurrent Developments in Biotechnology and Bioengineeringde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBioreactor modede_CH
dc.subjectKey engineering issuede_CH
dc.subjectMammalian cellde_CH
dc.subjectMicroorganismde_CH
dc.subjectReusablede_CH
dc.subjectSingle usede_CH
dc.subjectTransport phenomenomde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleStirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processesde_CH
dc.typeBuchbeitragde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/B978-0-444-63663-8.00007-0de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end215de_CH
zhaw.pages.start179de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewEditorial reviewde_CH
zhaw.webfeedVerfahrenstechnikde_CH
zhaw.author.additionalNode_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Jossen, V., Eibl-Schindler, R., Pörtner, R., Kraume, M., & Eibl, D. (2017). Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes. In Current Developments in Biotechnology and Bioengineering (pp. 179–215). Elsevier. https://doi.org/10.1016/B978-0-444-63663-8.00007-0
Jossen, V. et al. (2017) ‘Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes’, in Current Developments in Biotechnology and Bioengineering. Elsevier, pp. 179–215. Available at: https://doi.org/10.1016/B978-0-444-63663-8.00007-0.
V. Jossen, R. Eibl-Schindler, R. Pörtner, M. Kraume, and D. Eibl, “Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes,” in Current Developments in Biotechnology and Bioengineering, Elsevier, 2017, pp. 179–215. doi: 10.1016/B978-0-444-63663-8.00007-0.
JOSSEN, Valentin, Regine EIBL-SCHINDLER, Ralf PÖRTNER, Matthias KRAUME und Dieter EIBL, 2017. Stirred bioreactors : current state and developments, with special emphasis on biopharmaceutical production processes. In: Current Developments in Biotechnology and Bioengineering. Elsevier. S. 179–215. ISBN 9780444636638
Jossen, Valentin, Regine Eibl-Schindler, Ralf Pörtner, Matthias Kraume, and Dieter Eibl. 2017. “Stirred Bioreactors : Current State and Developments, with Special Emphasis on Biopharmaceutical Production Processes.” In Current Developments in Biotechnology and Bioengineering, 179–215. Elsevier. https://doi.org/10.1016/B978-0-444-63663-8.00007-0.
Jossen, Valentin, et al. “Stirred Bioreactors : Current State and Developments, with Special Emphasis on Biopharmaceutical Production Processes.” Current Developments in Biotechnology and Bioengineering, Elsevier, 2017, pp. 179–215, https://doi.org/10.1016/B978-0-444-63663-8.00007-0.


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