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dc.contributor.authorVoss, Moritz-
dc.contributor.authorHonda Malca, Sumire-
dc.contributor.authorBuller, Rebecca-
dc.date.accessioned2020-01-29T09:52:16Z-
dc.date.available2020-01-29T09:52:16Z-
dc.date.issued2020-01-22-
dc.identifier.issn0947-6539de_CH
dc.identifier.issn1521-3765de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/19230-
dc.description.abstractFreestanding non-heme iron halogenases are α-ketoglutarate dependent oxidoreductases that catalyze the installation of halogen atoms into unactivated sp 3 -hybridized carbon centers with high stereo- and regioselectivity. Since their discovery in 2014, a small number of indole-alkaloid and amino acid halogenases have been identified and characterized. First enzyme engineering examples suggest that the accessible substrate range of these enzymes may be expanded through the use of rational enzyme design and directed evolution. Structural investigations of non-heme iron halogenases acting of freestanding as well as tethered substrate are beginning to inform about the principles of the underlying halogenation mechanism.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofChemistry - A European Journalde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectC-H activationde_CH
dc.subjectFe/ αKG-dependent Halogenasesde_CH
dc.subjectBiocatalysisde_CH
dc.subjectEnzyme Engineeringde_CH
dc.subjectGenome Miningde_CH
dc.subject.ddc660.6: Biotechnologiede_CH
dc.titleExploring the biocatalytic potential of Fe/α‐ketoglutarate dependent halogenasesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/chem.201905752de_CH
dc.identifier.pmid31968136de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBiokatalysede_CH
zhaw.author.additionalNode_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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