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dc.contributor.authorTrifan, Adriana-
dc.contributor.authorVasincu, Alexandru-
dc.contributor.authorLuca, Simon Vlad-
dc.contributor.authorNeophytou, Christiana-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorOpitz, Sebastian-
dc.contributor.authorSava, Daciana-
dc.contributor.authorBucur, Laura-
dc.contributor.authorCioroiu, Bogdan I.-
dc.contributor.authorMiron, Anca-
dc.contributor.authorAprotosoaie, Ana Clara-
dc.contributor.authorCioanca, Oana-
dc.contributor.authorHancianu, Monica-
dc.contributor.authorJitareanu, Alexandra-
dc.contributor.authorConstantinou, Andreas I.-
dc.date.accessioned2019-12-11T10:01:44Z-
dc.date.available2019-12-11T10:01:44Z-
dc.date.issued2019-
dc.identifier.issn0278-6915de_CH
dc.identifier.issn1873-6351de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/18869-
dc.description.abstractThe Romanian coastlines of the Black Sea have abundant seaweed resources, but little effort has been done to investigate their biological potential. The aim of the present study was to assess the in vitro antioxidant and anti-proliferative effects of Cystoseira barbata (Stackhouse) C. Agardh (Sargassaceae), a brown alga inhabiting the Black Sea coast of Romania. The 70% acetone, methanol and water extracts of C. barbata were evaluated for their total phenolic content, antioxidant activity and anti-proliferative potential against human tumor cell lines (pulmonary A549, colon HT-29, mammary MCF-7) and the non-tumor mammary epithelial MCF-10A cell line. C. barbata 70% acetone extract (CBAE) displayed the highest antioxidant and cytotoxic activities. The mechanism of CBAE anti-proliferative activity involved initially increased intracellular ROS accumulation, followed by increased DNA content in the subG1 phase and DNA fragmentation leading to excessive apoptosis. Thus, our study provides a theoretical basis for the use of CBAE as a tumor preventive agent. Furthermore, UHPLC-DAD-QTOF-MS analysis of CBAE tentatively identified 18 phlorotannins as fucophlorethol and eckol derivatives, containing three up to seven phloroglucinol units. In conclusion, C. barbata represents a valuable source for the development of macroalgal-based products with putative use as nutraceuticals and pharmaceuticals.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofFood and Chemical Toxicologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAnti-proliferative activityde_CH
dc.subjectApoptosisde_CH
dc.subjectPhlorotanninsde_CH
dc.subjectBrown algaede_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleUnravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardhde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.fct.2019.110820de_CH
dc.identifier.pmid31539616de_CH
zhaw.funding.euNode_CH
zhaw.issue110820de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume134de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPhytopharmaziede_CH
zhaw.author.additionalNode_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Trifan, A., Vasincu, A., Luca, S. V., Neophytou, C., Wolfram, E., Opitz, S., Sava, D., Bucur, L., Cioroiu, B. I., Miron, A., Aprotosoaie, A. C., Cioanca, O., Hancianu, M., Jitareanu, A., & Constantinou, A. I. (2019). Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh. Food and Chemical Toxicology, 134(110820). https://doi.org/10.1016/j.fct.2019.110820
Trifan, A. et al. (2019) ‘Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh’, Food and Chemical Toxicology, 134(110820). Available at: https://doi.org/10.1016/j.fct.2019.110820.
A. Trifan et al., “Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh,” Food and Chemical Toxicology, vol. 134, no. 110820, 2019, doi: 10.1016/j.fct.2019.110820.
TRIFAN, Adriana, Alexandru VASINCU, Simon Vlad LUCA, Christiana NEOPHYTOU, Evelyn WOLFRAM, Sebastian OPITZ, Daciana SAVA, Laura BUCUR, Bogdan I. CIOROIU, Anca MIRON, Ana Clara APROTOSOAIE, Oana CIOANCA, Monica HANCIANU, Alexandra JITAREANU und Andreas I. CONSTANTINOU, 2019. Unravelling the potential of seaweeds from the Black Sea coast of Romania as bioactive compounds sources : part I: Cystoseira barbata (Stackhouse) C. Agardh. Food and Chemical Toxicology. 2019. Bd. 134, Nr. 110820. DOI 10.1016/j.fct.2019.110820
Trifan, Adriana, Alexandru Vasincu, Simon Vlad Luca, Christiana Neophytou, Evelyn Wolfram, Sebastian Opitz, Daciana Sava, et al. 2019. “Unravelling the Potential of Seaweeds from the Black Sea Coast of Romania as Bioactive Compounds Sources : Part I: Cystoseira Barbata (Stackhouse) C. Agardh.” Food and Chemical Toxicology 134 (110820). https://doi.org/10.1016/j.fct.2019.110820.
Trifan, Adriana, et al. “Unravelling the Potential of Seaweeds from the Black Sea Coast of Romania as Bioactive Compounds Sources : Part I: Cystoseira Barbata (Stackhouse) C. Agardh.” Food and Chemical Toxicology, vol. 134, no. 110820, 2019, https://doi.org/10.1016/j.fct.2019.110820.


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