| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Gene expression profiles of different breast cancer cells compared with their responsiveness to fermented mistletoe (Viscum album L.) extracts Iscador from oak (Quercus), pine (Pinus), white fir (Abies) and apple tree (Malus) in vitro |
| Autor/-in: | Eggenschwiler, Jenny Patrignani, Andrea Wagner, Ulrich Rehrauer, Hubert Schlapbach, Ralph Rist, Lukas Ramos, Mac Viviani, Angelika |
| DOI: | 10.1055/s-0031-1296816 |
| Erschienen in: | Drug Research |
| Band(Heft): | 56 |
| Heft: | 6a |
| Seite(n): | 483 |
| Seiten bis: | 496 |
| Erscheinungsdatum: | 2006 |
| Verlag / Hrsg. Institution: | Thieme |
| ISSN: | 0004-4172 1616-7066 |
| Sprache: | Englisch |
| Schlagwörter: | Cytotoxicity; Mistletoe; MCF-7 |
| Fachgebiet (DDC): | 615: Pharmakologie und Therapeutik |
| Zusammenfassung: | Cytotoxicity assays in vitro (MTT test) showed that the different breast cancer cell lines Kpl-1, MCF-7 and Mfm-223 respond differently to the mistletoe (Viscum album L.) preparations Iscador. Quercus (Qu), Abies (A), Malus (M) and Pinus (P). In order to determine the differences in the responsiveness of the cells more exactly, the gene expression profiles were determined by cells, which were treated with Mistletoe extracts, compared with untreated control cells. Such differences can be analysed in more detail by looking at the gene expression using Human Whole Genome microarray chips (41,000 genes). The results of the transcriptome analyses suggested that Iscador preparations influenced the overregulation of genes regarding immune defense, stress response, apoptosis and cell-cell adhesion pathways. Within the Mfm-223-Zellen was the Genexpression in MCF-7 and Kpl-1. The MCF-7 cells were affected on the genes which are involved in cell-cell contacts whereas Kpl-1 responded to the mistletoe extracts by changing the mRNA levels of the immune and stress response pathways. Concerning the effects of the mistletoe extract, we conclude that Iscador Qu and M have a greater influence on the immune defense and stress response genes whereas Iscador A tends to affect the cell-cell adhesion and cytoskeleton pathways. In summary, cDNA microarray analyses give us information on whether a cancer cell is sensitive to mistletoe extracts in relation to how many genes are significantly overrepresented after mistletoe treatment, and whether a particular mistletoe extract is more effective on a specific cancer cell than the other preparation. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/15311 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Eggenschwiler, J., Patrignani, A., Wagner, U., Rehrauer, H., Schlapbach, R., Rist, L., Ramos, M., & Viviani, A. (2006). Gene expression profiles of different breast cancer cells compared with their responsiveness to fermented mistletoe (Viscum album L.) extracts Iscador from oak (Quercus), pine (Pinus), white fir (Abies) and apple tree (Malus) in vitro. Drug Research, 56(6a), 483–496. https://doi.org/10.1055/s-0031-1296816
Eggenschwiler, J. et al. (2006) ‘Gene expression profiles of different breast cancer cells compared with their responsiveness to fermented mistletoe (Viscum album L.) extracts Iscador from oak (Quercus), pine (Pinus), white fir (Abies) and apple tree (Malus) in vitro’, Drug Research, 56(6a), pp. 483–496. Available at: https://doi.org/10.1055/s-0031-1296816.
J. Eggenschwiler et al., “Gene expression profiles of different breast cancer cells compared with their responsiveness to fermented mistletoe (Viscum album L.) extracts Iscador from oak (Quercus), pine (Pinus), white fir (Abies) and apple tree (Malus) in vitro,” Drug Research, vol. 56, no. 6a, pp. 483–496, 2006, doi: 10.1055/s-0031-1296816.
EGGENSCHWILER, Jenny, Andrea PATRIGNANI, Ulrich WAGNER, Hubert REHRAUER, Ralph SCHLAPBACH, Lukas RIST, Mac RAMOS und Angelika VIVIANI, 2006. Gene expression profiles of different breast cancer cells compared with their responsiveness to fermented mistletoe (Viscum album L.) extracts Iscador from oak (Quercus), pine (Pinus), white fir (Abies) and apple tree (Malus) in vitro. Drug Research. 2006. Bd. 56, Nr. 6a, S. 483–496. DOI 10.1055/s-0031-1296816
Eggenschwiler, Jenny, Andrea Patrignani, Ulrich Wagner, Hubert Rehrauer, Ralph Schlapbach, Lukas Rist, Mac Ramos, and Angelika Viviani. 2006. “Gene Expression Profiles of Different Breast Cancer Cells Compared with Their Responsiveness to Fermented Mistletoe (Viscum Album L.) Extracts Iscador from Oak (Quercus), Pine (Pinus), White Fir (Abies) and Apple Tree (Malus) in Vitro.” Drug Research 56 (6a): 483–96. https://doi.org/10.1055/s-0031-1296816.
Eggenschwiler, Jenny, et al. “Gene Expression Profiles of Different Breast Cancer Cells Compared with Their Responsiveness to Fermented Mistletoe (Viscum Album L.) Extracts Iscador from Oak (Quercus), Pine (Pinus), White Fir (Abies) and Apple Tree (Malus) in Vitro.” Drug Research, vol. 56, no. 6a, 2006, pp. 483–96, https://doi.org/10.1055/s-0031-1296816.
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