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dc.contributor.authorNallet, Sophie-
dc.contributor.authorAmacker, Mario-
dc.contributor.authorWesterfeld, Nicole-
dc.contributor.authorBaldi, Lucia-
dc.contributor.authorKönig, Iwo-
dc.contributor.authorHacker, David L.-
dc.contributor.authorZaborosch, Christiane-
dc.contributor.authorZurbriggen, Rinaldo-
dc.contributor.authorWurm, Florian M.-
dc.date.accessioned2019-02-05T16:38:43Z-
dc.date.available2019-02-05T16:38:43Z-
dc.date.issued2009-
dc.identifier.issn0264-410Xde_CH
dc.identifier.issn1873-2518de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/15015-
dc.description.abstractAlthough respiratory syncytial virus (RSV) causes severe lower respiratory tract infection in infants and adults at risk, no RSV vaccine is currently available. In this report, efforts toward the generation of an RSV subunit vaccine using recombinant RSV fusion protein (rRSV-F) are described. The recombinant protein was produced by transient gene expression (TGE) in suspension-adapted human embryonic kidney cells (HEK-293E) in 4 L orbitally shaken bioreactors. It was then purified and formulated in immunostimulating reconstituted influenza virosomes (IRIVs). The candidate vaccine induced anti-RSV-F neutralizing antibodies in mice, and challenge studies in cotton rats are ongoing. If successful in preclinical and clinical trials, this will be the first recombinant subunit vaccine produced by large-scale TGE in mammalian cells.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofVaccinede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectViral antibodiesde_CH
dc.subjectCell linede_CH
dc.subjectInbred BALB C micede_CH
dc.subjectNeutralization testsde_CH
dc.subjectRecombinant fusion proteinsde_CH
dc.subjectRespiratory syncytial virus infectionsde_CH
dc.subjectRespiratory syncytial virus vaccinesde_CH
dc.subjectSubunit vaccinesde_CH
dc.subjectViral fusion proteinsde_CH
dc.subjectVirosomesde_CH
dc.subjectTransfectionde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleRespiratory syncytial virus subunit vaccine based on a recombinant fusion protein expressed transiently in mammalian cellsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.vaccine.2009.06.019de_CH
dc.identifier.pmid19559121de_CH
zhaw.funding.euNode_CH
zhaw.issue46de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end6419de_CH
zhaw.pages.start6415de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume27de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in Collections:Publikationen Life Sciences und Facility Management

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