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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-2771
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dc.contributor.authorEggenschwiler, Jenny-
dc.contributor.authorvon Balthazar, Leopold-
dc.contributor.authorStritt, Bianca-
dc.contributor.authorPruntsch, Doreen-
dc.contributor.authorRamos, Mac-
dc.contributor.authorUrech, Konrad-
dc.contributor.authorRist, Lukas-
dc.contributor.authorSimões-Wüst, A Paula-
dc.contributor.authorViviani, Angelika-
dc.date.accessioned2019-02-05T16:32:31Z-
dc.date.available2019-02-05T16:32:31Z-
dc.date.issued2007-
dc.identifier.issn1472-6882de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/15012-
dc.description.abstractBackground: Preparations of mistletoe (Viscum album) are the form of cancer treatment that is most frequently used in the complementary medicine. Previous work has shown that these preparations are able to exert cytotoxic effects on carcinoma cells, the extent of which might be influenced by the host tree species and by the content of mistletoe lectin. Methods: Using colorimetric assays, we have now compared the cytotoxic effects of Viscum album preparations (VAPs) obtained from mistletoe growing on oak (Quercus robur and Q. petraea, VAP-Qu), apple tree (Malus domestica,, VAP-M), pine (Pinus sylvestris, VAP-P) or white fir (Abies pectinata, VAP-A), on the in vitro growth of breast and bladder carcinoma cell lines. While MFM-223, KPL-1, MCF-7 and HCC-1937 were the breast carcinoma cell lines chosen, the panel of tested bladder carcinoma cells comprised the T-24, TCC-SUP, UM-UC-3 and J-82 cell lines. Results: Each of the VAPs inhibited cell growth, but the extent of this inhibition differed with the preparation and with the cell line. The concentrations of VAP-Qu, VAP-M and VAP-A which led to a 50 % reduction of cell growth (IC50) varied between 0.6 and 0.03 mg/ml. Higher concentrations of VAP-P were required to obtain a comparable effect. Purified mistletoe lectin I (MLI) led to an inhibition of breast carcinoma cell growth at concentrations lower than those of VAPs, but the sensitivity towards purified MLI did not parallel that towards VAPs. Bladder carcinoma cells were in most cases more sensitive to VAPs treatment than breast carcinoma cells. The total mistletoe lectin content was very high in VAP-Qu (54 ng/mg extract), intermediate in VAP-M (25 ng/mg extract), and very low in VAP-P (1.3 ng/mg extract) and in VAP-A (1 ng/mg extract). As to be expected from the low content of mistletoe lectin, VAP-P led to relatively weak cytotoxic effects. Most remarkably, however, the lectin-poor VAP-A revealed a cytotoxic effect comparable to, or even stronger than, that of the lectin-rich VAP-Qu, on all tested bladder and breast carcinoma cell lines. Conclusion: The results suggest the existence of cytotoxic components other than mistletoe lectin in VAP-A and reveal an unexpected potential of this preparation for the treatment of breast and bladder cancer.de_CH
dc.language.isoende_CH
dc.publisherBioMed Centralde_CH
dc.relation.ispartofBMC Complementary and Alternative Medicinede_CH
dc.rightshttp://creativecommons.org/licenses/by/2.0/de_CH
dc.subjectAbiesde_CH
dc.subjectPhytogenic antineoplastic agentsde_CH
dc.subjectBreast neoplasmsde_CH
dc.subjectTumor cell linede_CH
dc.subjectCell survivalde_CH
dc.subjectDown-regulationde_CH
dc.subjectUrinary bladder neoplasmsde_CH
dc.subjectViscum albumde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleMistletoe lectin is not the only cytotoxic component in fermented preparations of Viscum album from white fir (Abies pectinata)de_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.21256/zhaw-2771-
dc.identifier.doi10.1186/1472-6882-7-14de_CH
dc.identifier.pmid17493268de_CH
zhaw.funding.euNode_CH
zhaw.issue14de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume7de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedZellphysiologiede_CH
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Eggenschwiler, J., von Balthazar, L., Stritt, B., Pruntsch, D., Ramos, M., Urech, K., Rist, L., Simões-Wüst, A. P., & Viviani, A. (2007). Mistletoe lectin is not the only cytotoxic component in fermented preparations of Viscum album from white fir (Abies pectinata). BMC Complementary and Alternative Medicine, 7(14). https://doi.org/10.21256/zhaw-2771
Eggenschwiler, J. et al. (2007) ‘Mistletoe lectin is not the only cytotoxic component in fermented preparations of Viscum album from white fir (Abies pectinata)’, BMC Complementary and Alternative Medicine, 7(14). Available at: https://doi.org/10.21256/zhaw-2771.
J. Eggenschwiler et al., “Mistletoe lectin is not the only cytotoxic component in fermented preparations of Viscum album from white fir (Abies pectinata),” BMC Complementary and Alternative Medicine, vol. 7, no. 14, 2007, doi: 10.21256/zhaw-2771.
EGGENSCHWILER, Jenny, Leopold VON BALTHAZAR, Bianca STRITT, Doreen PRUNTSCH, Mac RAMOS, Konrad URECH, Lukas RIST, A Paula SIMÕES-WÜST und Angelika VIVIANI, 2007. Mistletoe lectin is not the only cytotoxic component in fermented preparations of Viscum album from white fir (Abies pectinata). BMC Complementary and Alternative Medicine. 2007. Bd. 7, Nr. 14. DOI 10.21256/zhaw-2771
Eggenschwiler, Jenny, Leopold von Balthazar, Bianca Stritt, Doreen Pruntsch, Mac Ramos, Konrad Urech, Lukas Rist, A Paula Simões-Wüst, and Angelika Viviani. 2007. “Mistletoe Lectin Is Not the Only Cytotoxic Component in Fermented Preparations of Viscum Album from White Fir (Abies Pectinata).” BMC Complementary and Alternative Medicine 7 (14). https://doi.org/10.21256/zhaw-2771.
Eggenschwiler, Jenny, et al. “Mistletoe Lectin Is Not the Only Cytotoxic Component in Fermented Preparations of Viscum Album from White Fir (Abies Pectinata).” BMC Complementary and Alternative Medicine, vol. 7, no. 14, 2007, https://doi.org/10.21256/zhaw-2771.


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