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  2. Life Sciences und Facility Management
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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorChen, Clarice-
dc.contributor.authorLoe, Felicia-
dc.contributor.authorBlocki, Anna-
dc.contributor.authorPeng, Yanxian-
dc.contributor.authorRaghunath, Michael-
dc.date.accessioned2018-10-29T09:20:40Z-
dc.date.available2018-10-29T09:20:40Z-
dc.date.issued2011-
dc.identifier.issn0169-409Xde_CH
dc.identifier.issn1872-8294de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/12210-
dc.description.abstractWith the advent of multicellular organisms, the exterior of the cells evolved dramatically from highly aqueous surroundings into an extracellular matrix and space crowded with macromolecules. Cell-based therapies require removal of cells from their crowded physiological context and propagating them in dilute culture medium to attain therapeutically relevant numbers whilst preserving their phenotype. However, bereft of their microenvironment, cells under perform and lose functionality. Major efforts currently aim to modify cell culture surfaces and build three dimensional scaffolds to improve this situation. We discuss here alternative strategies that enable cells to re-create their own microenvironment in vitro, using carbohydrate-based macromolecules as culture media additives that create an excluded volume effect at defined fraction volume occupancies. This biophysical approach dramatically enhances extracellular matrix deposition by differentiated cells and stem cells, and boosts progenitor cell differentiation and proliferation. We begin to understand how well cells really can perform ex vivo if given the chance.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofAdvanced Drug Delivery Reviewsde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc570: Biologiede_CH
dc.subject.ddc610: Medizin und Gesundheitde_CH
dc.titleApplying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapiesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1016/j.addr.2011.03.003de_CH
zhaw.funding.euNode_CH
zhaw.issue4-5de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end290de_CH
zhaw.pages.start277de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume63de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMetabolic Tissue Engineeringde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Chen, C., Loe, F., Blocki, A., Peng, Y., & Raghunath, M. (2011). Applying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapies. Advanced Drug Delivery Reviews, 63(4-5), 277–290. https://doi.org/10.1016/j.addr.2011.03.003
Chen, C. et al. (2011) ‘Applying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapies’, Advanced Drug Delivery Reviews, 63(4-5), pp. 277–290. Available at: https://doi.org/10.1016/j.addr.2011.03.003.
C. Chen, F. Loe, A. Blocki, Y. Peng, and M. Raghunath, “Applying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapies,” Advanced Drug Delivery Reviews, vol. 63, no. 4-5, pp. 277–290, 2011, doi: 10.1016/j.addr.2011.03.003.
CHEN, Clarice, Felicia LOE, Anna BLOCKI, Yanxian PENG und Michael RAGHUNATH, 2011. Applying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapies. Advanced Drug Delivery Reviews. 2011. Bd. 63, Nr. 4-5, S. 277–290. DOI 10.1016/j.addr.2011.03.003
Chen, Clarice, Felicia Loe, Anna Blocki, Yanxian Peng, and Michael Raghunath. 2011. “Applying Macromolecular Crowding to Enhance Extracellular Matrix Deposition and Its Remodeling in Vitro for Tissue Engineering and Cell-Based Therapies.” Advanced Drug Delivery Reviews 63 (4-5): 277–90. https://doi.org/10.1016/j.addr.2011.03.003.
Chen, Clarice, et al. “Applying Macromolecular Crowding to Enhance Extracellular Matrix Deposition and Its Remodeling in Vitro for Tissue Engineering and Cell-Based Therapies.” Advanced Drug Delivery Reviews, vol. 63, no. 4-5, 2011, pp. 277–90, https://doi.org/10.1016/j.addr.2011.03.003.


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