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dc.contributor.authorBolliger, Jeanne L.-
dc.contributor.authorOberholzer, Miriam-
dc.contributor.authorFrech, Christian M.-
dc.date.accessioned2018-09-12T12:15:20Z-
dc.date.available2018-09-12T12:15:20Z-
dc.date.issued2011-
dc.identifier.issn1615-4150de_CH
dc.identifier.issn1615-4169de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/10466-
dc.description.abstract2‐Aminopyridines are key structural cores of bioactive natural products, medicinally important compounds, and organic materials and thus, extremely valuable synthetic targets. The few reported 6‐substituted 2‐aminopyridines and the lack of flexible, efficient and general applicable methods for their synthesis demonstrates the urgent need of new methods for their preparation. Reactions between 2,6‐dibromopyridine and primary or secondary, cyclic or acyclic, and aliphatic or aromatic amines were shown to selectively yield the respective 6‐bromopyridine‐2‐amines in very high yields which were successfully used as substrates for subsequent C-C cross‐coupling reactions. The recently introduced dichloro‐bis[1‐(dicyclohexylphosphanyl)piperidine]palladium was used as catalyst for the cross‐coupling of 6‐bromopyridine‐2‐amines with arylboronic acids, diaryl‐ and dialkylzinc reagents or olefins and hence, is also an excellent C-C cross‐coupling catalyst for this type of substrate. Moreover, all the reaction protocols presented were in each of the catalyses uniformly applied. The scope of both the amination and the cross‐coupling reactions are well defined and allow one to simply adapt the reaction protocols directly to other amines and/or coupling partners and, thus, provide for the first time a very flexible and generally applicable reaction protocol to get access to 2‐aminopyridines.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofAdvanced Synthesis & Catalysisde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc540: Chemiede_CH
dc.titleAccess to 2-aminopyridines : compounds of great biological and chemical significancede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
dc.identifier.doi10.1002/adsc.201000942de_CH
zhaw.funding.euNode_CH
zhaw.issue6de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end954de_CH
zhaw.pages.start945de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume353de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Bolliger, J. L., Oberholzer, M., & Frech, C. M. (2011). Access to 2-aminopyridines : compounds of great biological and chemical significance. Advanced Synthesis & Catalysis, 353(6), 945–954. https://doi.org/10.1002/adsc.201000942
Bolliger, J.L., Oberholzer, M. and Frech, C.M. (2011) ‘Access to 2-aminopyridines : compounds of great biological and chemical significance’, Advanced Synthesis & Catalysis, 353(6), pp. 945–954. Available at: https://doi.org/10.1002/adsc.201000942.
J. L. Bolliger, M. Oberholzer, and C. M. Frech, “Access to 2-aminopyridines : compounds of great biological and chemical significance,” Advanced Synthesis & Catalysis, vol. 353, no. 6, pp. 945–954, 2011, doi: 10.1002/adsc.201000942.
BOLLIGER, Jeanne L., Miriam OBERHOLZER und Christian M. FRECH, 2011. Access to 2-aminopyridines : compounds of great biological and chemical significance. Advanced Synthesis & Catalysis. 2011. Bd. 353, Nr. 6, S. 945–954. DOI 10.1002/adsc.201000942
Bolliger, Jeanne L., Miriam Oberholzer, and Christian M. Frech. 2011. “Access to 2-Aminopyridines : Compounds of Great Biological and Chemical Significance.” Advanced Synthesis & Catalysis 353 (6): 945–54. https://doi.org/10.1002/adsc.201000942.
Bolliger, Jeanne L., et al. “Access to 2-Aminopyridines : Compounds of Great Biological and Chemical Significance.” Advanced Synthesis & Catalysis, vol. 353, no. 6, 2011, pp. 945–54, https://doi.org/10.1002/adsc.201000942.


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