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  2. Gesundheit
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  4. Publikationen Gesundheit
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dc.contributor.authorTester J., Nicole-
dc.contributor.authorFuller, David D.-
dc.contributor.authorFromm, Jason S.-
dc.contributor.authorSpiess, Martina R.-
dc.contributor.authorBehrman, Andrea L.-
dc.contributor.authorMateika, Jason H.-
dc.date.accessioned2022-09-08T08:32:07Z-
dc.date.available2022-09-08T08:32:07Z-
dc.date.issued2014-01-
dc.identifier.issn1073-449Xde_CH
dc.identifier.issn1535-4970de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/25562-
dc.description.abstractRationale: Intermittent stimulation of the respiratory system with hypoxia causes persistent increases in respiratory motor output (i.e., long-term facilitation) in animals with spinal cord injury. This paradigm, therefore, has been touted as a potential respiratory rehabilitation strategy. Objectives: To determine whether acute (daily) exposure to intermittent hypoxia can also evoke long-term facilitation of ventilation after chronic spinal cord injury in humans, and whether repeated daily exposure to intermittent hypoxia enhances the magnitude of this response. Methods: Eight individuals with incomplete spinal cord injury (.1 yr; cervical [n = 6], thoracic [n = 2]) were exposed to intermittent hypoxia (eight 2-min intervals of 8% oxygen) for 10 days. During all exposures, end-tidal carbon dioxide levels were maintained, on average, 2 mm Hg above resting values. Minute ventilation, tidal volume, and breathing frequency were measured before (baseline), during, and 30 minutes after intermittent hypoxia. Sham protocols consisted of exposure to room air and were administered to a subset of the participants (n = 4). Measurements and Main Results: Minute ventilation increased significantly for 30 minutes after acute exposure to intermittent hypoxia (P , 0.001), but not after sham exposure. However, the magnitude of ventilatory long-term facilitation was not enhanced over 10 days of intermittent hypoxia exposures. Conclusions: Ventilatory long-term facilitation can be evoked by brief periods of hypoxia in humans with chronic spinal cord injury. Thus, intermittent hypoxia may represent a strategy for inducing respiratory neuroplasticity after declines in respiratory function that are related to neurological impairment. Clinical trial registered with www.clinicaltrials.gov (NCT01272011).de_CH
dc.language.isoende_CH
dc.publisherAmerican Thoracic Societyde_CH
dc.relation.ispartofAmerican Journal of Respiratory and Critical Care Medicinede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAdultde_CH
dc.subjectAgedde_CH
dc.subjectFemalede_CH
dc.subjectForced expiratory volumede_CH
dc.subjectHumansde_CH
dc.subjectLong-term carede_CH
dc.subjectMalede_CH
dc.subjectMiddle agedde_CH
dc.subjectRespiratory mechanicsde_CH
dc.subjectRespiratory therapyde_CH
dc.subjectSpinal cord Injuryde_CH
dc.subjectVital capacityde_CH
dc.subjectHypoxiade_CH
dc.subjectPulmonary ventilationde_CH
dc.subjectRespirationde_CH
dc.subjectPlasticityde_CH
dc.subjectIntermittent hypoxiade_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.subject.ddc617: Chirurgiede_CH
dc.titleLong-term facilitation of ventilation in humans with chronic spinal cord injuryde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Ergotherapie (IER)de_CH
dc.identifier.doi10.1164/rccm.201305-0848OCde_CH
dc.identifier.pmid24224903de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end65de_CH
zhaw.pages.start57de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume189de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Tester J., N., Fuller, D. D., Fromm, J. S., Spiess, M. R., Behrman, A. L., & Mateika, J. H. (2014). Long-term facilitation of ventilation in humans with chronic spinal cord injury. American Journal of Respiratory and Critical Care Medicine, 189(1), 57–65. https://doi.org/10.1164/rccm.201305-0848OC
Tester J., N. et al. (2014) ‘Long-term facilitation of ventilation in humans with chronic spinal cord injury’, American Journal of Respiratory and Critical Care Medicine, 189(1), pp. 57–65. Available at: https://doi.org/10.1164/rccm.201305-0848OC.
N. Tester J., D. D. Fuller, J. S. Fromm, M. R. Spiess, A. L. Behrman, and J. H. Mateika, “Long-term facilitation of ventilation in humans with chronic spinal cord injury,” American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 1, pp. 57–65, Jan. 2014, doi: 10.1164/rccm.201305-0848OC.
TESTER J., Nicole, David D. FULLER, Jason S. FROMM, Martina R. SPIESS, Andrea L. BEHRMAN und Jason H. MATEIKA, 2014. Long-term facilitation of ventilation in humans with chronic spinal cord injury. American Journal of Respiratory and Critical Care Medicine. Januar 2014. Bd. 189, Nr. 1, S. 57–65. DOI 10.1164/rccm.201305-0848OC
Tester J., Nicole, David D. Fuller, Jason S. Fromm, Martina R. Spiess, Andrea L. Behrman, and Jason H. Mateika. 2014. “Long-Term Facilitation of Ventilation in Humans with Chronic Spinal Cord Injury.” American Journal of Respiratory and Critical Care Medicine 189 (1): 57–65. https://doi.org/10.1164/rccm.201305-0848OC.
Tester J., Nicole, et al. “Long-Term Facilitation of Ventilation in Humans with Chronic Spinal Cord Injury.” American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 1, Jan. 2014, pp. 57–65, https://doi.org/10.1164/rccm.201305-0848OC.


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