Pregnancies in liver and kidney transplant recipients : a review of the current literature and recommendation

Blume, C.; Pischke, S.; von Versen-Höynck, F.; Günter, H.H.; Gross, Mechthild Maria

doi:10.1016/j.bpobgyn.2014.07.021

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Pregnancies in liver and kidney transplant recipients : a review of the current literature and recommendation
Authors:	Blume, C. Pischke, S. von Versen-Höynck, F. Günter, H.H. Gross, Mechthild Maria
DOI:	10.1016/j.bpobgyn.2014.07.021
Published in:	Best Practice & Research: Clinical Obstetrics & Gynaecology
Volume(Issue):	28
Issue:	8
Page(s):	1123
Pages to:	1136
Issue Date:	2014
Publisher / Ed. Institution:	Elsevier
ISSN:	1521-6934 1532-1932
Language:	English
Subjects:	Bone density conservation agents; Evidence-based medicine; Practice guidelines as topic; Pregnancy complications; Pregnancy outcome; Risk factor; Trace element; Transplant recipient; Vitamin D; Immunosuppression; Kidney transplantation; Liver transplantation
Subject (DDC):	618: Gynecology, obstetrics and midwifery
Abstract:	In this article, we focus on the biggest groups of organ transplant recipients, patients with a kidney or liver graft. Among these patients, about one sixth included women of childbearing potential. Therefore, the wish of getting pregnant is frequent in these peculiar patients, and careful planning and management of the pregnancies requires the expertise of obstetricians, midwives and transplant experts. Altogether, the outcome of the pregnancies in these women is acceptable. About 75% off all pregnancies ended successfully with live births, and this is comparable if not superior to pregnancies in healthy women. This success might be caused not only by the special and intensive care provided to these high-risk pregnancies by the transplant centres but also by the low rate of unplanned pregnancies. The risk of rejections and organ loss after delivery is about 10%, and it is slightly enhanced in liver transplant recipients (LTRs) in comparison to kidney graft recipients (KTRs) but the number of organ losses in direct association with a pregnancy is rare. However, there is not only a higher frequency of pregnancy-associated disorders such as pre-eclampsia and preterm delivery but also an acceleration of hypertension, new-onset diabetes mellitus and newly arising infections also favoured by the maintained immunosuppressive therapy. This implies a specialized 'control system' for these pregnant women that comprises ultrasound and Doppler investigation for risk assessment, infection screening, suitable therapy and the choice of non-teratogenic immunosuppressives. Antihypertensive treatment must be well balanced and adjusted to the possible growth-retarding effect on the foetus as well as on the co-morbidity of the mother. Finally, supplementation of vitamin D and iron is much more important in these transplanted women than in healthy pregnant women as vitamin D deficiency and anaemia are discussed to have an impact on pre-eclampsia and preterm delivery. These claims are widely discussed. Furthermore, the current literature is systematically reviewed by Scopus analysis.
URI:	https://digitalcollection.zhaw.ch/handle/11475/8144
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Midwifery and Reproductive Health (IHG)
Appears in collections:	Publikationen Gesundheit

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Blume, C., Pischke, S., von Versen-Höynck, F., Günter, H. H., & Gross, M. M. (2014). Pregnancies in liver and kidney transplant recipients : a review of the current literature and recommendation. Best Practice & Research: Clinical Obstetrics & Gynaecology, 28(8), 1123–1136. https://doi.org/10.1016/j.bpobgyn.2014.07.021

Blume, C. et al. (2014) ‘Pregnancies in liver and kidney transplant recipients : a review of the current literature and recommendation’, Best Practice & Research: Clinical Obstetrics & Gynaecology, 28(8), pp. 1123–1136. Available at: https://doi.org/10.1016/j.bpobgyn.2014.07.021.

C. Blume, S. Pischke, F. von Versen-Höynck, H. H. Günter, and M. M. Gross, “Pregnancies in liver and kidney transplant recipients : a review of the current literature and recommendation,” Best Practice & Research: Clinical Obstetrics & Gynaecology, vol. 28, no. 8, pp. 1123–1136, 2014, doi: 10.1016/j.bpobgyn.2014.07.021.

BLUME, C., S. PISCHKE, F. VON VERSEN-HÖYNCK, H.H. GÜNTER und Mechthild Maria GROSS, 2014. Pregnancies in liver and kidney transplant recipients : a review of the current literature and recommendation. Best Practice & Research: Clinical Obstetrics & Gynaecology. 2014. Bd. 28, Nr. 8, S. 1123–1136. DOI 10.1016/j.bpobgyn.2014.07.021

Blume, C., S. Pischke, F. von Versen-Höynck, H.H. Günter, and Mechthild Maria Gross. 2014. “Pregnancies in Liver and Kidney Transplant Recipients : A Review of the Current Literature and Recommendation.” Best Practice & Research: Clinical Obstetrics & Gynaecology 28 (8): 1123–36. https://doi.org/10.1016/j.bpobgyn.2014.07.021.

Blume, C., et al. “Pregnancies in Liver and Kidney Transplant Recipients : A Review of the Current Literature and Recommendation.” Best Practice & Research: Clinical Obstetrics & Gynaecology, vol. 28, no. 8, 2014, pp. 1123–36, https://doi.org/10.1016/j.bpobgyn.2014.07.021.