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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-30148
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dc.contributor.authorKirkeleit, Jorunn-
dc.contributor.authorRiise, Trond-
dc.contributor.authorWielscher, Mathias-
dc.contributor.authorAccordini, Simone-
dc.contributor.authorCarsin, Anne-Elie-
dc.contributor.authorDratva, Julia-
dc.contributor.authorFranklin, Karl A.-
dc.contributor.authorGarcia-Aymerich, Judith-
dc.contributor.authorJarvis, Deborah-
dc.contributor.authorLeynaert, Benedicte-
dc.contributor.authorLodge, Caroline J.-
dc.contributor.authorReal, Francisco Gomez-
dc.contributor.authorSchlünssen, Vivi-
dc.contributor.authorCorsico, Angelo Guido-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorHolm, Matthias-
dc.contributor.authorJanson, Christer-
dc.contributor.authorBenediktsdóttir, Bryndis-
dc.contributor.authorJogi, Rain-
dc.contributor.authorDharmage, Shyamali C.-
dc.contributor.authorJärvelin, Marjo-Riitta-
dc.contributor.authorSvanes, Cecilie-
dc.date.accessioned2024-03-09T17:55:06Z-
dc.date.available2024-03-09T17:55:06Z-
dc.date.issued2023-12-
dc.identifier.issn2589-5370de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/30148-
dc.description.abstractBackground: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. Methods: Participants (20–68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991–2013 and 1997–2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. Interpretation: Mothers’ smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofeClinicalMedicinede_CH
dc.rightshttps://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectAccelerated declinede_CH
dc.subjectEarly life risk factorde_CH
dc.subjectFEV1de_CH
dc.subjectFEV1/FVC ratiode_CH
dc.subjectFVCde_CH
dc.subjectLung functionde_CH
dc.subjectMaternal asthmade_CH
dc.subjectMaternal smokingde_CH
dc.subjectPaternal asthmade_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleEarly life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general populationde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Public Health (IPH)de_CH
dc.identifier.doi10.1016/j.eclinm.2023.102339de_CH
dc.identifier.doi10.21256/zhaw-30148-
dc.identifier.pmid38089857de_CH
zhaw.funding.euNode_CH
zhaw.issue102339de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume66de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedG: Gesundheit von Kindern und Jugendlichende_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Kirkeleit, J., Riise, T., Wielscher, M., Accordini, S., Carsin, A.-E., Dratva, J., Franklin, K. A., Garcia-Aymerich, J., Jarvis, D., Leynaert, B., Lodge, C. J., Real, F. G., Schlünssen, V., Corsico, A. G., Heinrich, J., Holm, M., Janson, C., Benediktsdóttir, B., Jogi, R., et al. (2023). Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population. eClinicalMedicine, 66(102339). https://doi.org/10.1016/j.eclinm.2023.102339
Kirkeleit, J. et al. (2023) ‘Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population’, eClinicalMedicine, 66(102339). Available at: https://doi.org/10.1016/j.eclinm.2023.102339.
J. Kirkeleit et al., “Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population,” eClinicalMedicine, vol. 66, no. 102339, Dec. 2023, doi: 10.1016/j.eclinm.2023.102339.
KIRKELEIT, Jorunn, Trond RIISE, Mathias WIELSCHER, Simone ACCORDINI, Anne-Elie CARSIN, Julia DRATVA, Karl A. FRANKLIN, Judith GARCIA-AYMERICH, Deborah JARVIS, Benedicte LEYNAERT, Caroline J. LODGE, Francisco Gomez REAL, Vivi SCHLÜNSSEN, Angelo Guido CORSICO, Joachim HEINRICH, Matthias HOLM, Christer JANSON, Bryndis BENEDIKTSDÓTTIR, Rain JOGI, Shyamali C. DHARMAGE, Marjo-Riitta JÄRVELIN und Cecilie SVANES, 2023. Early life exposures contributing to accelerated lung function decline in adulthood : a follow-up study of 11,000 adults from the general population. eClinicalMedicine. Dezember 2023. Bd. 66, Nr. 102339. DOI 10.1016/j.eclinm.2023.102339
Kirkeleit, Jorunn, Trond Riise, Mathias Wielscher, Simone Accordini, Anne-Elie Carsin, Julia Dratva, Karl A. Franklin, et al. 2023. “Early Life Exposures Contributing to Accelerated Lung Function Decline in Adulthood : A Follow-up Study of 11,000 Adults from the General Population.” eClinicalMedicine 66 (102339). https://doi.org/10.1016/j.eclinm.2023.102339.
Kirkeleit, Jorunn, et al. “Early Life Exposures Contributing to Accelerated Lung Function Decline in Adulthood : A Follow-up Study of 11,000 Adults from the General Population.” eClinicalMedicine, vol. 66, no. 102339, Dec. 2023, https://doi.org/10.1016/j.eclinm.2023.102339.


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