Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-24019
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dc.contributor.authorSeiler, Annina-
dc.contributor.authorBlum, David-
dc.contributor.authorDeuel, Jeremy Werner-
dc.contributor.authorHertler, Caroline-
dc.contributor.authorSchettle, Markus-
dc.contributor.authorZipser, Carl Moritz-
dc.contributor.authorErnst, Jutta-
dc.contributor.authorSchubert, Maria-
dc.contributor.authorvon Känel, Roland-
dc.contributor.authorBoettger, Soenke-
dc.date.accessioned2022-01-27T15:45:53Z-
dc.date.available2022-01-27T15:45:53Z-
dc.date.issued2021-
dc.identifier.issn1478-9515de_CH
dc.identifier.issn1478-9523de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/24019-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractObjective: Delirium is a frequent complication in advanced cancer patients, among whom it is frequently underdiagnosed and inadequately treated. To date, evidence on risk factors and the prognostic impact of delirium on outcomes remains sparse in this patient population. Method: In this prospective observational cohort study at a single tertiary-care center, 1,350 cancer patients were enrolled. Simple and multiple logistic regression models were utilized to identify associations between predisposing and precipitating factors and delirium. Cox proportional-hazards models were used to estimate the effect of delirium on death rate. Results: In our patient cohort, the prevalence of delirium was 34.3%. Delirium was associated inter alia with prolonged hospitalization, a doubling of care requirements, increased healthcare costs, increased need for institutionalization (OR 3.22), and increased mortality (OR 8.78). Predisposing factors for delirium were impaired activity (OR 10.82), frailty (OR 4.75); hearing (OR 2.23) and visual impairment (OR 1.89), chronic pneumonitis (OR 2.62), hypertension (OR 1.46), and renal insufficiency (OR 1.82). Precipitating factors were acute renal failure (OR 7.50), pressure sores (OR 3.78), pain (OR 2.86), and cystitis (OR 1.32). On multivariate Cox regression, delirium increased the mortality risk sixfold (HR 5.66). Age ≥ 65 years and comorbidities further doubled the mortality risk of delirious patients (HR 1.77; HR 2.05). Significance of results: Delirium is common in cancer patients and associated with increased morbidity and mortality. Systematically categorizing predisposing and precipitating factors might yield new strategies for preventing and managing delirium in cancer patients.de_CH
dc.language.isoende_CH
dc.publisherCambridge University Pressde_CH
dc.relation.ispartofPalliative & Supportive Carede_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectCancer patientde_CH
dc.subjectDeliriumde_CH
dc.subjectMorbidityde_CH
dc.subjectMortalityde_CH
dc.subjectPrecipitating factorde_CH
dc.subjectPredisposing factorde_CH
dc.subjectAgedde_CH
dc.subjectCohort studyde_CH
dc.subjectHumande_CH
dc.subjectPrevalencede_CH
dc.subjectProspective studyde_CH
dc.subjectRisk factorde_CH
dc.subjectHospital mortalityde_CH
dc.subjectNeoplasmde_CH
dc.subject.ddc610.73: Pflegede_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleDelirium is associated with an increased morbidity and in-hospital mortality in cancer patients : results from a prospective cohort studyde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Pflege (IPF)de_CH
dc.identifier.doi10.1017/S147895152000139Xde_CH
dc.identifier.doi10.21256/zhaw-24019-
dc.identifier.pmid33431093de_CH
zhaw.funding.euNode_CH
zhaw.issue3de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end303de_CH
zhaw.pages.start294de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume19de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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