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dc.contributor.authorErbas, Bircan-
dc.contributor.authorKnudsen, Toril Mørkve-
dc.contributor.authorJanson, Christer-
dc.contributor.authorNilsen, Roy M.-
dc.contributor.authorAccordini, Simone-
dc.contributor.authorBenediktdottir, Bryndis-
dc.contributor.authorDratva, Julia-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorJarvis, Debbie-
dc.contributor.authorLeynaert, Benedcite-
dc.contributor.authorMatheson, Melanie C.-
dc.contributor.authorNorbäck, Dan-
dc.contributor.authorReal, Francisco G.-
dc.contributor.authorRaherison-Semjen, Chantal-
dc.contributor.authorVillani, Simona-
dc.contributor.authorDharmage, S.C.-
dc.contributor.authorSvanes, C.-
dc.date.accessioned2019-07-22T09:25:57Z-
dc.date.available2019-07-22T09:25:57Z-
dc.date.issued2018-
dc.identifier.issn0013-9351de_CH
dc.identifier.issn1096-0953de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/17593-
dc.description.abstractBackground: Despite extensive knowledge of smoking effects on respiratory disease, there is no study including all age windows of exposure among ever smokers. The objective of this study was to assess the effects from smoking exposure in utero, early childhood, adolescence and adulthood on respiratory health outcomes in adult male and female ever smokers. Methods: Respiratory health outcomes were assessed in 10,610 participants of the European Community Respiratory Health Survey (ECRHS) I who reported a history of ever smoking by questionnaire. The associations of maternal smoking in utero, maternal smoking during childhood, age of smoking debut and pack-years of smoking with respiratory symptoms, obstructive diseases and bronchial hyperreactivity were analysed using generalized linear regression, non-linearity between age of smoking debut and outcomes were assessed by Generalized additive mixed models. Results: Respiratory symptoms and asthma were more frequent in adults if their mother smoked during pregnancy, and, in men, also if mother smoked in childhood. Wheeze and ≥3 respiratory symptoms declined with later smoking debut among women [≤10 years: OR = 3.51, 95% CI 1.26, 9.73; 11–12 years: 1.57[1.01–2.44]; 13–15 years: 1.11[0.94–1.32] and ≤10 years: 3.74[1.56–8.83]; 11–12 years: 1.76[1.19–2.56]; 13–15 years: 1.12[0.94–1.35], respectively]. Effects of increasing number of packyears were pronounced in women (Chronic Obstructive Pulmonary Disease (COPD): OR/10 packyears women: 1.33 [1.18, 1.50], men: 1.14 [1.04, 1.26] pinteraction = 0.01). Conclusions: Among ever smokers, smoking exposure in each stage of the lifespan show persistent harmful effects for adult respiratory health, while women appeared to be more vulnerable to an early age of smoking debut and amount of smoking in adulthood.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofEnvironmental Researchde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAsthmade_CH
dc.subjectCigarette smokingde_CH
dc.subjectECRHSde_CH
dc.subjectLung functionde_CH
dc.subjectRespiratory symptomde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleCritical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokersde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Gesundheitswissenschaften (IGW)de_CH
dc.identifier.doi10.1016/j.envres.2018.02.028de_CH
dc.identifier.pmid29522998de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end247de_CH
zhaw.pages.start241de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume164de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
Appears in collections:Publikationen Gesundheit

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