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dc.contributor.authorCrawford, Rebecca J.-
dc.contributor.authorVolken, Thomas-
dc.contributor.authorMhuiris, Áine Ni-
dc.contributor.authorBow, Cora C.-
dc.contributor.authorElliott, James M.-
dc.contributor.authorHoggarth, Mark A-
dc.contributor.authorSamartzis, Dino-
dc.description.abstractStudy Design: Cross-sectional Objective: We quantified fatty infiltration (FI) geography of the lumbar spine to identify whether demographics, temporal low back pain (LBP), and disability influence FI patterns. Summary of Background Data: Lumbar paravertebral muscle FI has been associated with age, sex, LBP, and disability; yet, FI accumulation patterns are inadequately described to optimise interventions. Methods: This cross-sectional study employed lumbar axial T1-weighted MRI in 107 Southern-Chinese adults (54 females, 53 males). Single-slices at the vertebral inferior end-plate per lumbar level were measured for quartiled-FI, and analysed against demographics, LBP, and disability (ODI: Oswestry Disability Index). Results: Mean FI% was higher in females, on the right, increased per level caudally, and from medial to lateral in men (p < 0.05). FI linearly increased with age for both sexes (p < 0.01) and was notably higher at L4&5 than L1,2&3 for cases aged 40-65yrs. BMI and FI were unrelated in females and inversely in males (p < 0.001). Females with LBPweek and males with LBPyear had 1.7% (each) less average FI (p < 0.05) than those without pain at that time-point. Men locating their LBP in the back had less FI than those without pain (p < 0.001). Disability was unrelated to FI for both sexes (p > 0.05). Conclusions: Lumbar paravertebral muscle FI predominates in the lower lumbar spine, notably for those aged 40-65, and depends more on sagittal than transverse distribution. Higher FI in females and differences of mean FI between sexes for BMI, LBP, and disabling ODI suggest sex-differential accumulation patterns. Our study contradicts pain models rationalising lumbar muscle FI and may reflect a normative sex-dependent feature of the natural history of lumbar paravertebral muscles.de_CH
dc.publisherLippincott Williams & Wilkinsde_CH
dc.subjectLow back painde_CH
dc.subjectDisc degenerationde_CH
dc.subjectFatty infiltrationde_CH
dc.subject.ddc616.7: Krankheiten des Bewegungsapparates und Orthopädiede_CH
dc.titleGeography of lumbar paravertebral muscle fatty infiltrationde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
zhaw.organisationalunitInstitut für Public Health (IPH)de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Crawford, R. J., Volken, T., Mhuiris, Á. N., Bow, C. C., Elliott, J. M., Hoggarth, M. A., & Samartzis, D. (2019). Geography of lumbar paravertebral muscle fatty infiltration. Spine.
Crawford, R.J. et al. (2019) ‘Geography of lumbar paravertebral muscle fatty infiltration’, Spine [Preprint]. Available at:
R. J. Crawford et al., “Geography of lumbar paravertebral muscle fatty infiltration,” Spine, 2019, doi: 10.21256/zhaw-3231.
CRAWFORD, Rebecca J., Thomas VOLKEN, Áine Ni MHUIRIS, Cora C. BOW, James M. ELLIOTT, Mark A HOGGARTH und Dino SAMARTZIS, 2019. Geography of lumbar paravertebral muscle fatty infiltration. Spine. 2019. DOI 10.21256/zhaw-3231
Crawford, Rebecca J., Thomas Volken, Áine Ni Mhuiris, Cora C. Bow, James M. Elliott, Mark A Hoggarth, and Dino Samartzis. 2019. “Geography of Lumbar Paravertebral Muscle Fatty Infiltration.” Spine.
Crawford, Rebecca J., et al. “Geography of Lumbar Paravertebral Muscle Fatty Infiltration.” Spine, 2019,

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