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dc.contributor.authorBolten, Margarete-
dc.contributor.authorNast, Irina-
dc.contributor.authorSkrundz, Marta-
dc.contributor.authorStadler, Christina-
dc.contributor.authorHellhammer, Dirk H.-
dc.contributor.authorMeinlschmidt, Gunther-
dc.date.accessioned2019-01-23T10:27:10Z-
dc.date.available2019-01-23T10:27:10Z-
dc.date.issued2013-
dc.identifier.issn0022-3999de_CH
dc.identifier.issn1879-1360de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/14513-
dc.description.abstractObjective: Hypothalamic-pituitary-adrenal (HPA) activation during pregnancy is linked to dysfunctional behavioral outcomes in the offspring. According to Belsky's differential susceptibility hypothesis, individuals vary regarding their developmental plasticity. Translating the differential susceptibility hypothesis to the field of fetal programming, we hypothesize that infants' temperament, as the constitutionally based reactivity to stimulation, moderates prenatal environmental effects on postnatal emotion regulation. Methods: Maternal HPA axis activity and stress-reactivity during pregnancy was estimated, by measuring cortisol concentrations in saliva, collected at 0, 30, 45 and 60 min after awakening and in blood, collected during a laboratory stress test (Trier Social Stress Test), respectively. Newborns reactivity to stimulation was evaluated between postnatal day 10 and 14 using the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Infant's self-quieting-activities, as an indicator of emotion regulation, were evaluated at the age of six months during the still face paradigm. Results: Maternal cortisol reactivity to stress during pregnancy was associated with infant's emotion regulation at the age of six months. Whereas cortisol levels after awakening in mid and late pregnancy were not associated with emotion regulation. Furthermore, regression analyses revealed that in interaction with neonatal reactivity, both, prenatal maternal HPA activity as well as prenatal maternal HPA reactivity to stress predicted emotion regulation. Conclusion: The findings indicate that newborns' reactivity to stimulation is moderating the association between prenatal exposure to maternal glucocorticoids and emotion regulation in infancy. Data suggests that temperamental characteristics of the newborn are a relevant differential susceptibility factor with regard to prenatal effects on emotion regulation.de_CH
dc.language.isoende_CH
dc.publisherElsevierde_CH
dc.relation.ispartofJournal of Psychosomatic Researchde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectEmotion-regulationde_CH
dc.subjectHPA axisde_CH
dc.subjectInfancyde_CH
dc.subjectNICU Network Neurobehavioral Scalede_CH
dc.subjectPrenatal stressde_CH
dc.subjectReactivityde_CH
dc.subjectTemperamentde_CH
dc.subjectArea under the curve with respect to increasede_CH
dc.subjecthypothalamic-pituitary-adrenal axisde_CH
dc.subjectAdultde_CH
dc.subjectBiomarkersde_CH
dc.subjectFemalede_CH
dc.subjectHumansde_CH
dc.subjectHydrocortisonede_CH
dc.subjectHypothalamo-Hypophyseal Systemde_CH
dc.subjectInfantde_CH
dc.subjectInfant, Newbornde_CH
dc.subjectMalede_CH
dc.subjectPituitary-Adrenal Systemde_CH
dc.subjectPregnancyde_CH
dc.subjectPregnancy Complicationsde_CH
dc.subjectPrenatal Exposure Delayed Effectsde_CH
dc.subjectSalivade_CH
dc.subjectStress, Psychologicalde_CH
dc.subjectEmotionsde_CH
dc.subjectFetal Developmentde_CH
dc.subjectPregnant Womende_CH
dc.subject.ddc150: Psychologiede_CH
dc.subject.ddc618: Geburtsmedizin und Hebammenarbeitde_CH
dc.titlePrenatal programming of emotion regulation : neonatal reactivity as a differential susceptibility factor moderating the outcome of prenatal cortisol levelsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Physiotherapie (IPT)de_CH
dc.identifier.doi10.1016/j.jpsychores.2013.04.014de_CH
dc.identifier.pmid24119942de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end357de_CH
zhaw.pages.start351de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume75de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Bolten, M., Nast, I., Skrundz, M., Stadler, C., Hellhammer, D. H., & Meinlschmidt, G. (2013). Prenatal programming of emotion regulation : neonatal reactivity as a differential susceptibility factor moderating the outcome of prenatal cortisol levels. Journal of Psychosomatic Research, 75(4), 351–357. https://doi.org/10.1016/j.jpsychores.2013.04.014
Bolten, M. et al. (2013) ‘Prenatal programming of emotion regulation : neonatal reactivity as a differential susceptibility factor moderating the outcome of prenatal cortisol levels’, Journal of Psychosomatic Research, 75(4), pp. 351–357. Available at: https://doi.org/10.1016/j.jpsychores.2013.04.014.
M. Bolten, I. Nast, M. Skrundz, C. Stadler, D. H. Hellhammer, and G. Meinlschmidt, “Prenatal programming of emotion regulation : neonatal reactivity as a differential susceptibility factor moderating the outcome of prenatal cortisol levels,” Journal of Psychosomatic Research, vol. 75, no. 4, pp. 351–357, 2013, doi: 10.1016/j.jpsychores.2013.04.014.
BOLTEN, Margarete, Irina NAST, Marta SKRUNDZ, Christina STADLER, Dirk H. HELLHAMMER und Gunther MEINLSCHMIDT, 2013. Prenatal programming of emotion regulation : neonatal reactivity as a differential susceptibility factor moderating the outcome of prenatal cortisol levels. Journal of Psychosomatic Research. 2013. Bd. 75, Nr. 4, S. 351–357. DOI 10.1016/j.jpsychores.2013.04.014
Bolten, Margarete, Irina Nast, Marta Skrundz, Christina Stadler, Dirk H. Hellhammer, and Gunther Meinlschmidt. 2013. “Prenatal Programming of Emotion Regulation : Neonatal Reactivity as a Differential Susceptibility Factor Moderating the Outcome of Prenatal Cortisol Levels.” Journal of Psychosomatic Research 75 (4): 351–57. https://doi.org/10.1016/j.jpsychores.2013.04.014.
Bolten, Margarete, et al. “Prenatal Programming of Emotion Regulation : Neonatal Reactivity as a Differential Susceptibility Factor Moderating the Outcome of Prenatal Cortisol Levels.” Journal of Psychosomatic Research, vol. 75, no. 4, 2013, pp. 351–57, https://doi.org/10.1016/j.jpsychores.2013.04.014.


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