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dc.contributor.authorvan Steenbergen, Hanna W.-
dc.contributor.authorAletaha, Daniel-
dc.contributor.authorBeaart-van de Voorde, Liesbeth J. J.-
dc.contributor.authorBrouwer, Elisabeth-
dc.contributor.authorCodreanu, Catalin-
dc.contributor.authorCombe, Bernard-
dc.contributor.authorFonseca, João E.-
dc.contributor.authorHetland, Merete L.-
dc.contributor.authorHumby, Frances-
dc.contributor.authorKvien, Tore K.-
dc.contributor.authorNiedermann Schneider, Karin-
dc.contributor.authorNuño, Laura-
dc.contributor.authorOliver, Sue-
dc.contributor.authorRantapää-Dahlqvist, Solbritt-
dc.contributor.authorRaza, Karim-
dc.contributor.authorvan Schaardenburg, Dirkjan-
dc.contributor.authorSchett, Georg-
dc.contributor.authorDe Smet, Liesbeth-
dc.contributor.authorSzücs, Gabriella-
dc.contributor.authorVencovský, Jirí-
dc.contributor.authorWiland, Piotr-
dc.contributor.authorde Wit, Maarten-
dc.contributor.authorLandewé, Robert L.-
dc.contributor.authorvan der Helm-van Mil, Annette H. M.-
dc.date.accessioned2019-01-07T14:28:50Z-
dc.date.available2019-01-07T14:28:50Z-
dc.date.issued2016-10-06-
dc.identifier.issn0003-4967de_CH
dc.identifier.issn1468-2060de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/14206-
dc.description.abstractBackground: During the transition to rheumatoid arthritis (RA) many patients pass through a phase characterised by the presence of symptoms without clinically apparent synovitis. These symptoms are not well-characterised. This taskforce aimed to define the clinical characteristics of patients with arthralgia who are considered at risk for RA by experts based on their clinical experience. Methods: The taskforce consisted of 18 rheumatologists, 1 methodologist, 2 patients, 3 health professionals and 1 research fellow. The process had three phases. In phase I, a list of parameters considered characteristic for clinically suspect arthralgia (CSA) was derived; the most important parameters were selected by a three-phased Delphi approach. In phase II, the experts evaluated 50 existing patients on paper, classified them as CSA/no-CSA and indicated their level of confidence. A provisional set of parameters was derived. This was studied for validation in phase III, where all rheumatologists collected patients with and without CSA from their outpatient clinics. Results: The comprehensive list consisted of 55 parameters, of which 16 were considered most important. A multivariable model based on the data from phase II identified seven relevant parameters: symptom duration <1 year, symptoms of metacarpophalangeal (MCP) joints, morning stiffness duration ≥60 min, most severe symptoms in early morning, first-degree relative with RA, difficulty with making a fist and positive squeeze test of MCP joints. In phase III, the combination of these parameters was accurate in identifying patients with arthralgia who were considered at risk of developing RA (area under the receiver operating characteristic curve 0.92, 95% CI 0.87 to 0.96). Test characteristics for different cut-off points were determined. Conclusions: A set of clinical characteristics for patients with arthralgia who are at risk of progression to RA was established.de_CH
dc.language.isoende_CH
dc.publisherBMJ Publishing Groupde_CH
dc.relation.ispartofAnnals of the Rheumatic Diseasesde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectEarly Rheumatoid Arthritisde_CH
dc.subjectOutcomes researchde_CH
dc.subjectRheumatoid Arthritisde_CH
dc.subjectArthralgiade_CH
dc.subjectArthritisde_CH
dc.subjectCircadian Rhythmde_CH
dc.subjectConsensusde_CH
dc.subjectDelphi Techniquede_CH
dc.subjectHumansde_CH
dc.subjectMetacarpophalangeal Jointde_CH
dc.subjectRange of Motion, Articularde_CH
dc.subjectRisk Assessmentde_CH
dc.subjectRisk Factorsde_CH
dc.subjectSensitivity and Specificityde_CH
dc.subjectTime Factorsde_CH
dc.subjectRheumatoidde_CH
dc.subject.ddc616.7: Krankheiten des Bewegungsapparates und Orthopädiede_CH
dc.titleEULAR definition of arthralgia suspicious for progression to rheumatoid arthritisde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Physiotherapie (IPT)de_CH
dc.identifier.doi10.1136/annrheumdis-2016-209846de_CH
dc.identifier.pmid27991858de_CH
zhaw.funding.euNode_CH
zhaw.issue3de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end496de_CH
zhaw.pages.start491de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume76de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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van Steenbergen, H. W., Aletaha, D., Beaart-van de Voorde, L. J. J., Brouwer, E., Codreanu, C., Combe, B., Fonseca, J. E., Hetland, M. L., Humby, F., Kvien, T. K., Niedermann Schneider, K., Nuño, L., Oliver, S., Rantapää-Dahlqvist, S., Raza, K., van Schaardenburg, D., Schett, G., De Smet, L., Szücs, G., et al. (2016). EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis. Annals of the Rheumatic Diseases, 76(3), 491–496. https://doi.org/10.1136/annrheumdis-2016-209846
van Steenbergen, H.W. et al. (2016) ‘EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis’, Annals of the Rheumatic Diseases, 76(3), pp. 491–496. Available at: https://doi.org/10.1136/annrheumdis-2016-209846.
H. W. van Steenbergen et al., “EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 76, no. 3, pp. 491–496, Oct. 2016, doi: 10.1136/annrheumdis-2016-209846.
VAN STEENBERGEN, Hanna W., Daniel ALETAHA, Liesbeth J. J. BEAART-VAN DE VOORDE, Elisabeth BROUWER, Catalin CODREANU, Bernard COMBE, João E. FONSECA, Merete L. HETLAND, Frances HUMBY, Tore K. KVIEN, Karin NIEDERMANN SCHNEIDER, Laura NUÑO, Sue OLIVER, Solbritt RANTAPÄÄ-DAHLQVIST, Karim RAZA, Dirkjan VAN SCHAARDENBURG, Georg SCHETT, Liesbeth DE SMET, Gabriella SZÜCS, Jirí VENCOVSKÝ, Piotr WILAND, Maarten DE WIT, Robert L. LANDEWÉ und Annette H. M. VAN DER HELM-VAN MIL, 2016. EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis. Annals of the Rheumatic Diseases. 6 Oktober 2016. Bd. 76, Nr. 3, S. 491–496. DOI 10.1136/annrheumdis-2016-209846
van Steenbergen, Hanna W., Daniel Aletaha, Liesbeth J. J. Beaart-van de Voorde, Elisabeth Brouwer, Catalin Codreanu, Bernard Combe, João E. Fonseca, et al. 2016. “EULAR Definition of Arthralgia Suspicious for Progression to Rheumatoid Arthritis.” Annals of the Rheumatic Diseases 76 (3): 491–96. https://doi.org/10.1136/annrheumdis-2016-209846.
van Steenbergen, Hanna W., et al. “EULAR Definition of Arthralgia Suspicious for Progression to Rheumatoid Arthritis.” Annals of the Rheumatic Diseases, vol. 76, no. 3, Oct. 2016, pp. 491–96, https://doi.org/10.1136/annrheumdis-2016-209846.


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