Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-4814
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dc.contributor.authorDratva, Julia-
dc.contributor.authorCaviezel, Seraina-
dc.contributor.authorSchaffner, Emmanuel-
dc.contributor.authorStolz, Daiana-
dc.contributor.authorRothe, Thomas-
dc.contributor.authorKuenzli, Nino-
dc.contributor.authorSchmidt-Trucksäss, Arno-
dc.contributor.authorZemp, Elisabeth-
dc.contributor.authorProbst-Hensch, Nicole-
dc.date.accessioned2018-09-20T06:57:53Z-
dc.date.available2018-09-20T06:57:53Z-
dc.date.issued2018-02-06-
dc.identifier.issn0340-6199de_CH
dc.identifier.issn1432-1076de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/10833-
dc.descriptionErworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)de_CH
dc.description.abstractRespiratory diseases are associated with increased cardiovascular risk in adults, but little is known on the early impact on the vasculature in youth. The SAPALDIA Youth study, the offspring study of the Swiss Study on Air Pollution and Lung and Heart Disease In Adults (SAPALDIA), investigated the association between physician-diagnosed asthma status and common carotid artery intima media thickness (CIMT). Offspring underwent standardized clinical protocols and provided information on early life factors, health, and lifestyle. The association between per subject averages of CIMT and asthma was estimated using mixed linear regression analyses adjusting for main confounders, testing for interaction with gender and age. Of 257 offspring (mean age 15 years, 53% female), 11.5% reported doctor-diagnosed asthma (male 17%, female 7%). Mean CIMT was significantly different by gender (male 0.53 mm (± 0.045), female 0.50 mm (± 0.048); p < 0.001). Interaction was highly significant by gender (p = 0.001) with significantly increased CIMT in asthmatic vs. non-asthmatics boys (difference 0.023 mm, 95% CI 0.003; 0.043), as compared to girls. Conclusion: Our study suggests an increased risk for early vascular change in adolescent asthmatic boys. Whereas the small number of girls limits the interpretation, the result necessitates further research into sex-specific atherosclerotic burden related to respiratory health in adolescence.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofEuropean journal of pediatricsde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAsthmade_CH
dc.subjectAtherosclerosisde_CH
dc.subjectCarotid intima media thicknessde_CH
dc.subjectEpidemiologyde_CH
dc.subjectAdolescentde_CH
dc.subjectAsthmade_CH
dc.subjectAtherosclerosisde_CH
dc.subjectCarotid Arteriesde_CH
dc.subjectChildde_CH
dc.subjectCross-Sectional Studiesde_CH
dc.subjectFemalede_CH
dc.subjectHumansde_CH
dc.subjectMalede_CH
dc.subjectRisk Factorsde_CH
dc.subjectSwitzerlandde_CH
dc.subjectCarotid Intima-Media Thicknessde_CH
dc.subjectSex Factorsde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.subject.ddc618.92: Pädiatriede_CH
dc.titleIs there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?de_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Gesundheitswissenschaften (IGW)de_CH
dc.identifier.doi10.21256/zhaw-4814-
dc.identifier.doi10.1007/s00431-018-3107-0de_CH
dc.identifier.pmid29411143de_CH
zhaw.funding.euNode_CH
zhaw.issue5de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end707de_CH
zhaw.pages.start699de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume177de_CH
zhaw.embargo.end2023-05-01de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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