| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein |
| Autor/-in: | Schweizer, Anja Rohrer, Jack Jenö, Paul DeMaio, Antonio Buchman, Timothy G. Hauri, Hans-Peter |
| Erschienen in: | Journal of Cell Science |
| Band(Heft): | 104 |
| Seite(n): | 685 |
| Seiten bis: | 694 |
| Erscheinungsdatum: | 1993 |
| Verlag / Hrsg. Institution: | The Company of Biologists |
| ISSN: | 0021-9533 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | The recently identified 63 kDa membrane protein, p63, is a resident protein of a membrane network interposed in between rough ER and Golgi apparatus. To characterize p63 at the molecular level a 2.91 kb cDNA encoding p63 has been isolated from a human placenta lambda gt10 cDNA library. Sequence analysis of tryptic peptides prepared from isolated p63 confirmed the identify of the cloned gene. The translated amino acid sequence consists of 601 amino acids (65.8 kDa) with a single putative membrane-spanning region and a N-terminal cytoplasmic domain of 106 amino acids. The human p63 cDNA exhibits a high level of sequence identify to the pig hepatic cDNA 3AL (accession number M27092) whose expression is enhanced after resuscitation from circulatory shock. An additional remarkable feature of p63 is that it becomes reversibly palmitoylated when intracellular protein transport is blocked by the drug brefeldin A. Overexpression of p63 in COS cells led to the development of a striking tubular membrane network in the cytoplasm. This suggests that the protein may be determinant for the structure of the p63 compartment. |
| URI: | http://jcs.biologists.org/content/104/3/685.short https://digitalcollection.zhaw.ch/handle/11475/6842 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Schweizer, A., Rohrer, J., Jenö, P., DeMaio, A., Buchman, T. G., & Hauri, H.-P. (1993). A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein. Journal of Cell Science, 104, 685–694. http://jcs.biologists.org/content/104/3/685.short
Schweizer, A. et al. (1993) ‘A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein’, Journal of Cell Science, 104, pp. 685–694. Available at: http://jcs.biologists.org/content/104/3/685.short.
A. Schweizer, J. Rohrer, P. Jenö, A. DeMaio, T. G. Buchman, and H.-P. Hauri, “A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein,” Journal of Cell Science, vol. 104, pp. 685–694, 1993, [Online]. Available: http://jcs.biologists.org/content/104/3/685.short
SCHWEIZER, Anja, Jack ROHRER, Paul JENÖ, Antonio DEMAIO, Timothy G. BUCHMAN und Hans-Peter HAURI, 1993. A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein. Journal of Cell Science [online]. 1993. Bd. 104, S. 685–694. Verfügbar unter: http://jcs.biologists.org/content/104/3/685.short
Schweizer, Anja, Jack Rohrer, Paul Jenö, Antonio DeMaio, Timothy G. Buchman, and Hans-Peter Hauri. 1993. “A Reversibly Palmitoylated Resident Protein (P63) of an ER-Golgi Intermediate Compartment Is Related to a Circulatory Shock Resuscitation Protein.” Journal of Cell Science 104: 685–94. http://jcs.biologists.org/content/104/3/685.short.
Schweizer, Anja, et al. “A Reversibly Palmitoylated Resident Protein (P63) of an ER-Golgi Intermediate Compartment Is Related to a Circulatory Shock Resuscitation Protein.” Journal of Cell Science, vol. 104, 1993, pp. 685–94, http://jcs.biologists.org/content/104/3/685.short.
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