A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein

Schweizer, Anja; Rohrer, Jack; Jenö, Paul; DeMaio, Antonio; Buchman, Timothy G.; Hauri, Hans-Peter

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein
Authors:	Schweizer, Anja Rohrer, Jack Jenö, Paul DeMaio, Antonio Buchman, Timothy G. Hauri, Hans-Peter
Published in:	Journal of Cell Science
Volume(Issue):	104
Page(s):	685
Pages to:	694
Issue Date:	1993
Publisher / Ed. Institution:	The Company of Biologists
ISSN:	0021-9533
Language:	English
Subject (DDC):	572: Biochemistry
Abstract:	The recently identified 63 kDa membrane protein, p63, is a resident protein of a membrane network interposed in between rough ER and Golgi apparatus. To characterize p63 at the molecular level a 2.91 kb cDNA encoding p63 has been isolated from a human placenta lambda gt10 cDNA library. Sequence analysis of tryptic peptides prepared from isolated p63 confirmed the identify of the cloned gene. The translated amino acid sequence consists of 601 amino acids (65.8 kDa) with a single putative membrane-spanning region and a N-terminal cytoplasmic domain of 106 amino acids. The human p63 cDNA exhibits a high level of sequence identify to the pig hepatic cDNA 3AL (accession number M27092) whose expression is enhanced after resuscitation from circulatory shock. An additional remarkable feature of p63 is that it becomes reversibly palmitoylated when intracellular protein transport is blocked by the drug brefeldin A. Overexpression of p63 in COS cells led to the development of a striking tubular membrane network in the cytoplasm. This suggests that the protein may be determinant for the structure of the p63 compartment.
URI:	http://jcs.biologists.org/content/104/3/685.short https://digitalcollection.zhaw.ch/handle/11475/6842
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Appears in collections:	Publikationen Life Sciences und Facility Management

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Schweizer, A., Rohrer, J., Jenö, P., DeMaio, A., Buchman, T. G., & Hauri, H.-P. (1993). A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein. Journal of Cell Science, 104, 685–694. http://jcs.biologists.org/content/104/3/685.short

Schweizer, A. et al. (1993) ‘A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein’, Journal of Cell Science, 104, pp. 685–694. Available at: http://jcs.biologists.org/content/104/3/685.short.

A. Schweizer, J. Rohrer, P. Jenö, A. DeMaio, T. G. Buchman, and H.-P. Hauri, “A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein,” Journal of Cell Science, vol. 104, pp. 685–694, 1993, [Online]. Available: http://jcs.biologists.org/content/104/3/685.short

SCHWEIZER, Anja, Jack ROHRER, Paul JENÖ, Antonio DEMAIO, Timothy G. BUCHMAN und Hans-Peter HAURI, 1993. A reversibly palmitoylated resident protein (p63) of an ER-golgi intermediate compartment is related to a circulatory shock resuscitation protein. Journal of Cell Science [online]. 1993. Bd. 104, S. 685–694. Verfügbar unter: http://jcs.biologists.org/content/104/3/685.short

Schweizer, Anja, Jack Rohrer, Paul Jenö, Antonio DeMaio, Timothy G. Buchman, and Hans-Peter Hauri. 1993. “A Reversibly Palmitoylated Resident Protein (P63) of an ER-Golgi Intermediate Compartment Is Related to a Circulatory Shock Resuscitation Protein.” Journal of Cell Science 104: 685–94. http://jcs.biologists.org/content/104/3/685.short.

Schweizer, Anja, et al. “A Reversibly Palmitoylated Resident Protein (P63) of an ER-Golgi Intermediate Compartment Is Related to a Circulatory Shock Resuscitation Protein.” Journal of Cell Science, vol. 104, 1993, pp. 685–94, http://jcs.biologists.org/content/104/3/685.short.