Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-1651
Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | Mechanical catalysis on the centimetre scale |
Authors: | Miyashita, Shuhei Audretsch, Christof Nagy, Zoltán Füchslin, Rudolf Marcel Pfeifer, Rolf |
DOI: | 10.21256/zhaw-1651 10.1098/rsif.2014.1271 |
Published in: | Journal of the Royal Society Interface |
Volume(Issue): | 12 |
Issue: | 104 |
Issue Date: | 2015 |
Publisher / Ed. Institution: | The Royal Society |
ISSN: | 1742-5689 |
Language: | English |
Subjects: | Magnetic catalysis; Enzyme; Inhibitor; Conformation change; Autocatalysis; Reaction phase |
Subject (DDC): | 540: Chemistry 572: Biochemistry |
Abstract: | Enzymes play important roles in catalysing biochemical transaction paths, acting as logical machines through the morphology of the processes. A key challenge in elucidating the nature of these systems, and for engineering manufacturing methods inspired by biochemical reactions, is to attain a comprehensive understanding of the stereochemical ground rules of enzymatic reactions. Here, we present a model of catalysis that can be performed magnetically by centimetre-sized passive floating units. The designed system, which is equipped with permanent magnets only, passively obeys the local causalities imposed by magnetic interactions, albeit it shows a spatial behaviour and an energy profile analogous to those of biochemical enzymes. In this process, the enzyme units trigger physical conformation changes of the target by levelling out the magnetic potential barrier (activation potential) to a funnel type and, thus, induce cascading conformation changes of the targeted substrate units reacting in parallel. The inhibitor units, conversely, suppress such changes by increasing the potential. Because the model is purely mechanical and established on a physics basis in the absence of turbulence, each performance can be explained by the morphology of the unit, extending the definition of catalysis to systems of alternative scales. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/2700 |
Fulltext version: | Published version |
License (according to publishing contract): | CC BY-NC 4.0: Attribution - Non commercial 4.0 International |
Departement: | School of Engineering |
Appears in collections: | Publikationen School of Engineering |
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2015_Miyashita_Mechanical catalysis on the centimetre scale_Journal of the Royal Society.pdf | 989.96 kB | Adobe PDF | View/Open |
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Miyashita, S., Audretsch, C., Nagy, Z., Füchslin, R. M., & Pfeifer, R. (2015). Mechanical catalysis on the centimetre scale. Journal of the Royal Society Interface, 12(104). https://doi.org/10.21256/zhaw-1651
Miyashita, S. et al. (2015) ‘Mechanical catalysis on the centimetre scale’, Journal of the Royal Society Interface, 12(104). Available at: https://doi.org/10.21256/zhaw-1651.
S. Miyashita, C. Audretsch, Z. Nagy, R. M. Füchslin, and R. Pfeifer, “Mechanical catalysis on the centimetre scale,” Journal of the Royal Society Interface, vol. 12, no. 104, 2015, doi: 10.21256/zhaw-1651.
MIYASHITA, Shuhei, Christof AUDRETSCH, Zoltán NAGY, Rudolf Marcel FÜCHSLIN und Rolf PFEIFER, 2015. Mechanical catalysis on the centimetre scale. Journal of the Royal Society Interface. 2015. Bd. 12, Nr. 104. DOI 10.21256/zhaw-1651
Miyashita, Shuhei, Christof Audretsch, Zoltán Nagy, Rudolf Marcel Füchslin, and Rolf Pfeifer. 2015. “Mechanical Catalysis on the Centimetre Scale.” Journal of the Royal Society Interface 12 (104). https://doi.org/10.21256/zhaw-1651.
Miyashita, Shuhei, et al. “Mechanical Catalysis on the Centimetre Scale.” Journal of the Royal Society Interface, vol. 12, no. 104, 2015, https://doi.org/10.21256/zhaw-1651.
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