| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases |
| Autor/-in: | Büchler, Johannes Hegarty, Eimear Schroer, Kirsten Snajdrova, Radka Turner, Nicholas J. Loiseleur, Olivier Buller, Rebecca Le Chapelain, Camille |
| et. al: | No |
| DOI: | 10.1002/hlca.202200128 |
| Erschienen in: | Helvetica Chimica Acta |
| Band(Heft): | 106 |
| Heft: | 1 |
| Seite(n): | e202200128 |
| Erscheinungsdatum: | 2022 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 0018-019X 1522-2675 |
| Sprache: | Englisch |
| Schlagwörter: | Biocatalysis; Enzyme engineering; Collaboration; Halogenation; Late-stage functionalization; Sustainable chemistry |
| Fachgebiet (DDC): | 660: Technische Chemie |
| Zusammenfassung: | In 2017, two companies, Novartis AG and Syngenta AG, joined forces with the group of Prof. Buller, head of the Competence Center for Biocatalysis (CCBIO), to tackle the challenge of enzymatic late-stage halogenation. This biocatalytic method was considered to provide a more sustainable approach to late-stage halogenation of complex molecules than traditional synthetic approaches. Using machine-learning guided protein engineering, α-ketoglutarate dependent halogenases were evolved into versatile catalysts capable of selectively chlorinating inactivated C−H bonds. Structurally diverse molecules, namely an analogue of martinelline as well as two members of the soraphen natural product family, were enzymatically chlorinated at two distinct positions in a regio- and stereoselective manner, thus demonstrating the synthetic usefulness of such a strategy. As part of our three-year collaboration, flavin-dependent halogenases were also studied. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/26410 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Büchler, J., Hegarty, E., Schroer, K., Snajdrova, R., Turner, N. J., Loiseleur, O., Buller, R., & Le Chapelain, C. (2022). A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases. Helvetica Chimica Acta, 106(1), e202200128. https://doi.org/10.1002/hlca.202200128
Büchler, J. et al. (2022) ‘A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases’, Helvetica Chimica Acta, 106(1), p. e202200128. Available at: https://doi.org/10.1002/hlca.202200128.
J. Büchler et al., “A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases,” Helvetica Chimica Acta, vol. 106, no. 1, p. e202200128, 2022, doi: 10.1002/hlca.202200128.
BÜCHLER, Johannes, Eimear HEGARTY, Kirsten SCHROER, Radka SNAJDROVA, Nicholas J. TURNER, Olivier LOISELEUR, Rebecca BULLER und Camille LE CHAPELAIN, 2022. A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases. Helvetica Chimica Acta. 2022. Bd. 106, Nr. 1, S. e202200128. DOI 10.1002/hlca.202200128
Büchler, Johannes, Eimear Hegarty, Kirsten Schroer, Radka Snajdrova, Nicholas J. Turner, Olivier Loiseleur, Rebecca Buller, and Camille Le Chapelain. 2022. “A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases.” Helvetica Chimica Acta 106 (1): e202200128. https://doi.org/10.1002/hlca.202200128.
Büchler, Johannes, et al. “A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases.” Helvetica Chimica Acta, vol. 106, no. 1, 2022, p. e202200128, https://doi.org/10.1002/hlca.202200128.
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