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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorBüchler, Johannes-
dc.contributor.authorHegarty, Eimear-
dc.contributor.authorSchroer, Kirsten-
dc.contributor.authorSnajdrova, Radka-
dc.contributor.authorTurner, Nicholas J.-
dc.contributor.authorLoiseleur, Olivier-
dc.contributor.authorBuller, Rebecca-
dc.contributor.authorLe Chapelain, Camille-
dc.date.accessioned2022-12-16T13:10:19Z-
dc.date.available2022-12-16T13:10:19Z-
dc.date.issued2022-
dc.identifier.issn0018-019Xde_CH
dc.identifier.issn1522-2675de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26410-
dc.description.abstractIn 2017, two companies, Novartis AG and Syngenta AG, joined forces with the group of Prof. Buller, head of the Competence Center for Biocatalysis (CCBIO), to tackle the challenge of enzymatic late-stage halogenation. This biocatalytic method was considered to provide a more sustainable approach to late-stage halogenation of complex molecules than traditional synthetic approaches. Using machine-learning guided protein engineering, α-ketoglutarate dependent halogenases were evolved into versatile catalysts capable of selectively chlorinating inactivated C−H bonds. Structurally diverse molecules, namely an analogue of martinelline as well as two members of the soraphen natural product family, were enzymatically chlorinated at two distinct positions in a regio- and stereoselective manner, thus demonstrating the synthetic usefulness of such a strategy. As part of our three-year collaboration, flavin-dependent halogenases were also studied.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofHelvetica Chimica Actade_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBiocatalysisde_CH
dc.subjectEnzyme engineeringde_CH
dc.subjectCollaborationde_CH
dc.subjectHalogenationde_CH
dc.subjectLate-stage functionalizationde_CH
dc.subjectSustainable chemistryde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleA collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenasesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/hlca.202200128de_CH
zhaw.funding.euNode_CH
zhaw.issue1de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.starte202200128de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume106de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedBiokatalysede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Büchler, J., Hegarty, E., Schroer, K., Snajdrova, R., Turner, N. J., Loiseleur, O., Buller, R., & Le Chapelain, C. (2022). A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases. Helvetica Chimica Acta, 106(1), e202200128. https://doi.org/10.1002/hlca.202200128
Büchler, J. et al. (2022) ‘A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases’, Helvetica Chimica Acta, 106(1), p. e202200128. Available at: https://doi.org/10.1002/hlca.202200128.
J. Büchler et al., “A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases,” Helvetica Chimica Acta, vol. 106, no. 1, p. e202200128, 2022, doi: 10.1002/hlca.202200128.
BÜCHLER, Johannes, Eimear HEGARTY, Kirsten SCHROER, Radka SNAJDROVA, Nicholas J. TURNER, Olivier LOISELEUR, Rebecca BULLER und Camille LE CHAPELAIN, 2022. A collaborative journey towards the late‐stage functionalization of added‐value chemicals using engineered halogenases. Helvetica Chimica Acta. 2022. Bd. 106, Nr. 1, S. e202200128. DOI 10.1002/hlca.202200128
Büchler, Johannes, Eimear Hegarty, Kirsten Schroer, Radka Snajdrova, Nicholas J. Turner, Olivier Loiseleur, Rebecca Buller, and Camille Le Chapelain. 2022. “A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases.” Helvetica Chimica Acta 106 (1): e202200128. https://doi.org/10.1002/hlca.202200128.
Büchler, Johannes, et al. “A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases.” Helvetica Chimica Acta, vol. 106, no. 1, 2022, p. e202200128, https://doi.org/10.1002/hlca.202200128.


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