Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study

Meier, Valeria S.; Beatrice, Laura; Turek, Michelle; Poirier, Valerie J.; Cancedda, Simona; Stiborova, Katerina; Körner, Maximilian; Marconato, Laura; Weyland, Mathias S.; Rohrer Bley, Carla

doi:10.1111/vco.12517

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study
Authors:	Meier, Valeria S. Beatrice, Laura Turek, Michelle Poirier, Valerie J. Cancedda, Simona Stiborova, Katerina Körner, Maximilian Marconato, Laura Weyland, Mathias S. Rohrer Bley, Carla
et. al:	No
DOI:	10.1111/vco.12517
Published in:	Veterinary and Comparative Oncology
Volume(Issue):	17
Issue:	4
Page(s):	528
Pages to:	536
Issue Date:	Dec-2019
Publisher / Ed. Institution:	Wiley
ISSN:	1476-5810 1476-5829
Language:	English
Subjects:	IMRT; Cancer; Feline; Lymphoproliferative; Nasal; Animal; Cat disease; Cat; Disease-free survival; Female; Lymphoma; Male; Neoplasm recurrence, local; Nose neoplasm; Retrospective study; Treatment outcome
Subject (DDC):	616: Internal medicine and diseases 630: Agriculture
Abstract:	Failure rate and site are not well defined in localized sinonasal lymphoma in cats treated with radiotherapy. In this study, we describe (a) failure pattern, (b) outcome, (c) influence of previously reported prognostic variables on the outcome in cats with suspected localized sinonasal lymphoma. In this multi-institutional retrospective study, we included 51 cats treated with single-modality radiotherapy. Cats were irradiated using 10x4.2Gy (n = 32), 12x3Gy (n = 11) or 5x6Gy (n = 8). Regional lymph nodes were prophylactically irradiated in 24/51 cats (47.1%). Twenty-five cats (49.0%) developed progressive disease: progression was local (nasal) in five (9.8%), locoregional (nodal) in two (3.9%), local and locoregional in three (5.9%), systemic in nine (17.6%) and both local and systemic in six cats (11.8%). No cat receiving prophylactic nodal irradiation had progression in the locoregional lymph nodes. The median time to progression was 974 days (95%CI: 283;1666), with 58% and 53% of cats free of progression at 1 and 2 years, respectively. Median overall survival was 922 days (95%CI: 66;1779) with 61% and 49% alive at 1 and 2 years, respectively. Half of the cats that died of relapse/progression (13/26) died within 6 months of treatment, suggesting possible shortcomings of staging, rapid dissemination of disease or sequential lymphomagenesis. None of the prognostic factors evaluated were predictive of outcome (prednisolone use, anaemia, nasopharyngeal involvement, modified canine Adams tumour stage, protocol, total dose). Radiotherapy is an effective treatment for localized sinonasal lymphoma with a long time to progression. However, in one-third of the cats, systemic disease progression occurs soon after radiotherapy.
URI:	https://digitalcollection.zhaw.ch/handle/11475/26088
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Engineering
Organisational Unit:	Institute of Applied Mathematics and Physics (IAMP)
Appears in collections:	Publikationen School of Engineering

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Meier, V. S., Beatrice, L., Turek, M., Poirier, V. J., Cancedda, S., Stiborova, K., Körner, M., Marconato, L., Weyland, M. S., & Rohrer Bley, C. (2019). Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study. Veterinary and Comparative Oncology, 17(4), 528–536. https://doi.org/10.1111/vco.12517

Meier, V.S. et al. (2019) ‘Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study’, Veterinary and Comparative Oncology, 17(4), pp. 528–536. Available at: https://doi.org/10.1111/vco.12517.

V. S. Meier et al., “Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study,” Veterinary and Comparative Oncology, vol. 17, no. 4, pp. 528–536, Dec. 2019, doi: 10.1111/vco.12517.

MEIER, Valeria S., Laura BEATRICE, Michelle TUREK, Valerie J. POIRIER, Simona CANCEDDA, Katerina STIBOROVA, Maximilian KÖRNER, Laura MARCONATO, Mathias S. WEYLAND und Carla ROHRER BLEY, 2019. Outcome and failure patterns of localized sinonasal lymphoma in cats treated with first-line single-modality radiation therapy : a retrospective study. Veterinary and Comparative Oncology. Dezember 2019. Bd. 17, Nr. 4, S. 528–536. DOI 10.1111/vco.12517

Meier, Valeria S., Laura Beatrice, Michelle Turek, Valerie J. Poirier, Simona Cancedda, Katerina Stiborova, Maximilian Körner, Laura Marconato, Mathias S. Weyland, and Carla Rohrer Bley. 2019. “Outcome and Failure Patterns of Localized Sinonasal Lymphoma in Cats Treated with First-Line Single-Modality Radiation Therapy : A Retrospective Study.” Veterinary and Comparative Oncology 17 (4): 528–36. https://doi.org/10.1111/vco.12517.

Meier, Valeria S., et al. “Outcome and Failure Patterns of Localized Sinonasal Lymphoma in Cats Treated with First-Line Single-Modality Radiation Therapy : A Retrospective Study.” Veterinary and Comparative Oncology, vol. 17, no. 4, Dec. 2019, pp. 528–36, https://doi.org/10.1111/vco.12517.