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https://doi.org/10.21256/zhaw-1584| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale |
| Autor/-in: | Demuth, Caspar Varonier, Joel Jossen, Valentin Eibl-Schindler, Regine Eibl, Dieter |
| DOI: | 10.21256/zhaw-1584 10.1007/s00253-016-7412-0 |
| Erschienen in: | Applied Microbiology and Biotechnology |
| Band(Heft): | 100 |
| Heft: | 9 |
| Seite(n): | 3853 |
| Seiten bis: | 3863 |
| Erscheinungsdatum: | Mai-2016 |
| Verlag / Hrsg. Institution: | Springer |
| Verlag / Hrsg. Institution: | Berlin |
| ISSN: | 0175-7598 1432-0614 |
| Sprache: | Englisch |
| Schlagwörter: | Optical sensors; Single-use cultivation systems; Bioprocess measurement and control; Sensors for pH and dissolved oxygen |
| Fachgebiet (DDC): | 660: Technische Chemie |
| Zusammenfassung: | pH value and the concentration of dissolved oxygen (DO) are key parameters to monitor and control cell growth in cultivation studies. Reliable, robust and accurate methods to measure these parameters in cultivation systems in real time guarantee high product yield and quality. This mini-review summarises the current state of the art of pH and DO sensors that are applied to bioprocesses from millilitre to benchtop scale by means of a short introduction on measuring principles and selected applications. Special emphasis is placed on single-use bioreactors, which have been increasingly employed in bioprocess development and production in recent years. Working principles, applications and the particular requirements of sensors in these cultivation systems are given. In such processes, optical sensors for pH and DO are often preferred to electrochemical probes, as they allow semi-invasive measurements and can be miniaturised to micrometre scale or lower. In addition, selected measuring principles of novel sensing technologies for pH and DO are discussed. These include solid-state sensors and miniaturised devices that are not yet commercially available, but show promising characteristics for possible use in bioprocesses in the near future. |
| Weitere Angaben: | Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch) |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2259 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Gesperrt bis: | 2021-04-01 |
| Departement: | Life Sciences und Facility Management |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2016_Demuth_Novel probes for pH and_Appl Microbiol Biotechnol.pdf | 528.2 kB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Demuth, C., Varonier, J., Jossen, V., Eibl-Schindler, R., & Eibl, D. (2016). Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale. Applied Microbiology and Biotechnology, 100(9), 3853–3863. https://doi.org/10.21256/zhaw-1584
Demuth, C. et al. (2016) ‘Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale’, Applied Microbiology and Biotechnology, 100(9), pp. 3853–3863. Available at: https://doi.org/10.21256/zhaw-1584.
C. Demuth, J. Varonier, V. Jossen, R. Eibl-Schindler, and D. Eibl, “Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale,” Applied Microbiology and Biotechnology, vol. 100, no. 9, pp. 3853–3863, May 2016, doi: 10.21256/zhaw-1584.
DEMUTH, Caspar, Joel VARONIER, Valentin JOSSEN, Regine EIBL-SCHINDLER und Dieter EIBL, 2016. Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale. Applied Microbiology and Biotechnology. Mai 2016. Bd. 100, Nr. 9, S. 3853–3863. DOI 10.21256/zhaw-1584
Demuth, Caspar, Joel Varonier, Valentin Jossen, Regine Eibl-Schindler, and Dieter Eibl. 2016. “Novel Probes for pH and Dissolved Oxygen Measurements in Cultivations from Millilitre to Benchtop Scale.” Applied Microbiology and Biotechnology 100 (9): 3853–63. https://doi.org/10.21256/zhaw-1584.
Demuth, Caspar, et al. “Novel Probes for pH and Dissolved Oxygen Measurements in Cultivations from Millilitre to Benchtop Scale.” Applied Microbiology and Biotechnology, vol. 100, no. 9, May 2016, pp. 3853–63, https://doi.org/10.21256/zhaw-1584.
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