| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods |
| Autor/-in: | Löffelholz, Christian Husemann, Ute Greller, Gerhard Meusel, Wolfram Kauling, Jörg Ay, Peter Kraume, Matthias Eibl-Schindler, Regine Eibl, Dieter |
| DOI: | 10.1002/cite.201200125 |
| Erschienen in: | Chemie Ingenieur Technik |
| Band(Heft): | 85 |
| Heft: | 1-2 |
| Seite(n): | 40 |
| Seiten bis: | 56 |
| Erscheinungsdatum: | Feb-2013 |
| Verlag / Hrsg. Institution: | Wiley |
| Verlag / Hrsg. Institution: | Weinheim |
| ISSN: | 0009-286X 1522-2640 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 660: Technische Chemie |
| Zusammenfassung: | During the past five years, the number of single-use bioreactors used in biopharmaceutical research and production has increased tremendously. This increase has been particularly associated with mammalian cell culture processes from small- to medium-scale volumes. Even though nowadays customers can choose from a multitude of 2nd and 3rd generation single-use bioreactors, ranging from mL- up to m3-scale, there is a lack of knowledge of their engineering parameters. Different approaches have been applied to characterization investigations, resulting in an inability to compare different single-use bioreactors with each other and their reusable counterparts, creating an obstacle to a systematic approach to scaling-up the process. This article describes parametric, experimental and computer-based numeric methods for biochemical engineering characterization of single-use bioreactors, which have already been used successfully for the characterization of their reusable counterparts. For the first time, these methods have been evaluated in terms of their practical application. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/2245 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Löffelholz, C., Husemann, U., Greller, G., Meusel, W., Kauling, J., Ay, P., Kraume, M., Eibl-Schindler, R., & Eibl, D. (2013). Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods. Chemie Ingenieur Technik, 85(1-2), 40–56. https://doi.org/10.1002/cite.201200125
Löffelholz, C. et al. (2013) ‘Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods’, Chemie Ingenieur Technik, 85(1-2), pp. 40–56. Available at: https://doi.org/10.1002/cite.201200125.
C. Löffelholz et al., “Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods,” Chemie Ingenieur Technik, vol. 85, no. 1-2, pp. 40–56, Feb. 2013, doi: 10.1002/cite.201200125.
LÖFFELHOLZ, Christian, Ute HUSEMANN, Gerhard GRELLER, Wolfram MEUSEL, Jörg KAULING, Peter AY, Matthias KRAUME, Regine EIBL-SCHINDLER und Dieter EIBL, 2013. Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods. Chemie Ingenieur Technik. Februar 2013. Bd. 85, Nr. 1-2, S. 40–56. DOI 10.1002/cite.201200125
Löffelholz, Christian, Ute Husemann, Gerhard Greller, Wolfram Meusel, Jörg Kauling, Peter Ay, Matthias Kraume, Regine Eibl-Schindler, and Dieter Eibl. 2013. “Bioengineering Parameters for Single-Use Bioreactors : Overview and Evaluation of Suitable Methods.” Chemie Ingenieur Technik 85 (1-2): 40–56. https://doi.org/10.1002/cite.201200125.
Löffelholz, Christian, et al. “Bioengineering Parameters for Single-Use Bioreactors : Overview and Evaluation of Suitable Methods.” Chemie Ingenieur Technik, vol. 85, no. 1-2, Feb. 2013, pp. 40–56, https://doi.org/10.1002/cite.201200125.
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