Title: Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods
Authors : Löffelholz, Christian
Husemann, Ute
Greller, Gerhard
Meusel, Wolfram
Kauling, Jörg
Ay, Peter
Kraume, Matthias
Eibl-Schindler, Regine
Eibl, Dieter
Published in : Chemie Ingenieur Technik
Volume(Issue) : 85
Issue : 1-2
Pages : 40
Pages to: 56
Publisher / Ed. Institution : Wiley VCH
Publisher / Ed. Institution: Weinheim
Issue Date: Feb-2013
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subject (DDC) : 660: Chemical engineering
Abstract: During the past five years, the number of single-use bioreactors used in biopharmaceutical research and production has increased tremendously. This increase has been particularly associated with mammalian cell culture processes from small- to medium-scale volumes. Even though nowadays customers can choose from a multitude of 2nd and 3rd generation single-use bioreactors, ranging from mL- up to m3-scale, there is a lack of knowledge of their engineering parameters. Different approaches have been applied to characterization investigations, resulting in an inability to compare different single-use bioreactors with each other and their reusable counterparts, creating an obstacle to a systematic approach to scaling-up the process. This article describes parametric, experimental and computer-based numeric methods for biochemical engineering characterization of single-use bioreactors, which have already been used successfully for the characterization of their reusable counterparts. For the first time, these methods have been evaluated in terms of their practical application.
Departement: Life Sciences und Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1002/cite.201200125
ISSN: 0009-286X
URI: https://digitalcollection.zhaw.ch/handle/11475/2245
Appears in Collections:Publikationen Life Sciences und Facility Management

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