|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods|
|Published in:||Chemie Ingenieur Technik|
|Publisher / Ed. Institution:||Wiley|
|Publisher / Ed. Institution:||Weinheim|
|Subject (DDC):||660: Chemical engineering|
|Abstract:||During the past five years, the number of single-use bioreactors used in biopharmaceutical research and production has increased tremendously. This increase has been particularly associated with mammalian cell culture processes from small- to medium-scale volumes. Even though nowadays customers can choose from a multitude of 2nd and 3rd generation single-use bioreactors, ranging from mL- up to m3-scale, there is a lack of knowledge of their engineering parameters. Different approaches have been applied to characterization investigations, resulting in an inability to compare different single-use bioreactors with each other and their reusable counterparts, creating an obstacle to a systematic approach to scaling-up the process. This article describes parametric, experimental and computer-based numeric methods for biochemical engineering characterization of single-use bioreactors, which have already been used successfully for the characterization of their reusable counterparts. For the first time, these methods have been evaluated in terms of their practical application.|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Appears in collections:||Publikationen Life Sciences und Facility Management|
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Löffelholz, C., Husemann, U., Greller, G., Meusel, W., Kauling, J., Ay, P., Kraume, M., Eibl-Schindler, R., & Eibl, D. (2013). Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods. Chemie Ingenieur Technik, 85(1-2), 40–56. https://doi.org/10.1002/cite.201200125
Löffelholz, C. et al. (2013) ‘Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods’, Chemie Ingenieur Technik, 85(1-2), pp. 40–56. Available at: https://doi.org/10.1002/cite.201200125.
C. Löffelholz et al., “Bioengineering parameters for single-use bioreactors : overview and evaluation of suitable methods,” Chemie Ingenieur Technik, vol. 85, no. 1-2, pp. 40–56, Feb. 2013, doi: 10.1002/cite.201200125.
Löffelholz, Christian, et al. “Bioengineering Parameters for Single-Use Bioreactors : Overview and Evaluation of Suitable Methods.” Chemie Ingenieur Technik, vol. 85, no. 1-2, Feb. 2013, pp. 40–56, https://doi.org/10.1002/cite.201200125.
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