Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
https://doi.org/10.21256/zhaw-22287| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Verbascum nigrum : cytotoxicity evaluation in A431 epidermoid carcinoma cells and untargeted LC‐HR‐MS/MS metabolite profiling |
| Autor/-in: | Iliescu, Iolanda Alca Peter, Samuel Albert, Ina Skalicka‐Woźniak, Krystyna Miron, Anca Luca, Simon Vlad Wolfram, Evelyn |
| et. al: | No |
| DOI: | 10.1002/cbdv.202000644 10.21256/zhaw-22287 |
| Erschienen in: | Chemistry & Biodiversity |
| Band(Heft): | 17 |
| Heft: | 12 |
| Seite(n): | e2000644 |
| Erscheinungsdatum: | 2020 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 1612-1872 1612-1880 |
| Sprache: | Englisch |
| Schlagwörter: | LC/HR-MS/MS; Verbascum nigrum; Cytotoxic activity; Saponin glycosides; Verbascoside |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | The crude methanolic extract obtained from Verbascum nigrum aerial parts (VNE) and its six fractions (VNF1-VNF6) were initially screened regarding their effects on the viability of immortalized HaCaT keratinocytes and A431 epidermoid carcinoma cells (MTT assay, 24 h). None of the tested samples affected the viability of HaCaT cells in a concentration range of 25-150 μg/mL. VNE and VNF4 exhibited significant cytotoxic effects in A431 cells, with IC50 values of 81.92 and 12.27 μg/mL, respectively; the selectivity index was higher than 10 for VNF4. The untargeted LC/HR-MS/MS metabolite profiling led to the tentative annotation of a total number of 23 compounds. Of these, VNE comprised mainly iridoid glycosides (harpagoside, laterioside, acylated aucubin derivatives), whereas VNF4 showed a high abundance of triterpene saponin glycosides (ilwensisaponins A and C, songarosaponins A and B), constituents known for their selective cytotoxic potential. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/22287 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2020_Iliescu-etal_Verbascum-nigrum-cytotoxicity-evaluation.pdf | 2.35 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Iliescu, I. A., Peter, S., Albert, I., Skalicka‐Woźniak, K., Miron, A., Luca, S. V., & Wolfram, E. (2020). Verbascum nigrum : cytotoxicity evaluation in A431 epidermoid carcinoma cells and untargeted LC‐HR‐MS/MS metabolite profiling. Chemistry & Biodiversity, 17(12), e2000644. https://doi.org/10.1002/cbdv.202000644
Iliescu, I.A. et al. (2020) ‘Verbascum nigrum : cytotoxicity evaluation in A431 epidermoid carcinoma cells and untargeted LC‐HR‐MS/MS metabolite profiling’, Chemistry & Biodiversity, 17(12), p. e2000644. Available at: https://doi.org/10.1002/cbdv.202000644.
I. A. Iliescu et al., “Verbascum nigrum : cytotoxicity evaluation in A431 epidermoid carcinoma cells and untargeted LC‐HR‐MS/MS metabolite profiling,” Chemistry & Biodiversity, vol. 17, no. 12, p. e2000644, 2020, doi: 10.1002/cbdv.202000644.
ILIESCU, Iolanda Alca, Samuel PETER, Ina ALBERT, Krystyna SKALICKA‐WOŹNIAK, Anca MIRON, Simon Vlad LUCA und Evelyn WOLFRAM, 2020. Verbascum nigrum : cytotoxicity evaluation in A431 epidermoid carcinoma cells and untargeted LC‐HR‐MS/MS metabolite profiling. Chemistry & Biodiversity. 2020. Bd. 17, Nr. 12, S. e2000644. DOI 10.1002/cbdv.202000644
Iliescu, Iolanda Alca, Samuel Peter, Ina Albert, Krystyna Skalicka‐Woźniak, Anca Miron, Simon Vlad Luca, and Evelyn Wolfram. 2020. “Verbascum Nigrum : Cytotoxicity Evaluation in A431 Epidermoid Carcinoma Cells and Untargeted LC‐HR‐MS/MS Metabolite Profiling.” Chemistry & Biodiversity 17 (12): e2000644. https://doi.org/10.1002/cbdv.202000644.
Iliescu, Iolanda Alca, et al. “Verbascum Nigrum : Cytotoxicity Evaluation in A431 Epidermoid Carcinoma Cells and Untargeted LC‐HR‐MS/MS Metabolite Profiling.” Chemistry & Biodiversity, vol. 17, no. 12, 2020, p. e2000644, https://doi.org/10.1002/cbdv.202000644.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.