| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals |
| Autor/-in: | Schroeder, Clemens Park, Min Tae M. Germann, Jürgen Chakravarty, M. Mallar Michels, Lars Kollias, Spyros Kroll, Sara L. Buck, Alfred Treyer, Valerie Savaskan, Egemen Unschuld, Paul G. Nitsch, Roger M. Kälin, Andrea M. Hock, Christoph Gietl, Anton F. Leh, Sandra E. |
| et. al: | No |
| DOI: | 10.1111/ejn.13408 |
| Erschienen in: | European Journal of Neuroscience |
| Band(Heft): | 45 |
| Heft: | 10 |
| Seite(n): | 1241 |
| Seiten bis: | 1251 |
| Erscheinungsdatum: | Mai-2017 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 0953-816X 1460-9568 |
| Sprache: | Englisch |
| Schlagwörter: | Alzheimer's disease; Beta-amyloid; Hippocampal shape; Magnetic resonance imaging; Positron emission tomography; Aged; Amyloid beta-Peptide; Hippocampus; Human; Radiopharmaceuticals |
| Fachgebiet (DDC): | 616.8: Neurologie und Krankheiten des Nervensystems |
| Zusammenfassung: | Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11-C-Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (P < 0.05, FDR corrected), whereas volumes of the hippocampi and their subregions were not associated with cortical or regional PiB uptake (all P > 0.05, FDR corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical PiB uptake (P < 0.05, FDR corrected). Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/20701 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Finanzen & Services |
| Enthalten in den Sammlungen: | Publikationen Finanzen & Services |
Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.
Zur Langanzeige
Schroeder, C., Park, M. T. M., Germann, J., Chakravarty, M. M., Michels, L., Kollias, S., Kroll, S. L., Buck, A., Treyer, V., Savaskan, E., Unschuld, P. G., Nitsch, R. M., Kälin, A. M., Hock, C., Gietl, A. F., & Leh, S. E. (2017). Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals. European Journal of Neuroscience, 45(10), 1241–1251. https://doi.org/10.1111/ejn.13408
Schroeder, C. et al. (2017) ‘Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals’, European Journal of Neuroscience, 45(10), pp. 1241–1251. Available at: https://doi.org/10.1111/ejn.13408.
C. Schroeder et al., “Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals,” European Journal of Neuroscience, vol. 45, no. 10, pp. 1241–1251, May 2017, doi: 10.1111/ejn.13408.
SCHROEDER, Clemens, Min Tae M. PARK, Jürgen GERMANN, M. Mallar CHAKRAVARTY, Lars MICHELS, Spyros KOLLIAS, Sara L. KROLL, Alfred BUCK, Valerie TREYER, Egemen SAVASKAN, Paul G. UNSCHULD, Roger M. NITSCH, Andrea M. KÄLIN, Christoph HOCK, Anton F. GIETL und Sandra E. LEH, 2017. Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals. European Journal of Neuroscience. Mai 2017. Bd. 45, Nr. 10, S. 1241–1251. DOI 10.1111/ejn.13408
Schroeder, Clemens, Min Tae M. Park, Jürgen Germann, M. Mallar Chakravarty, Lars Michels, Spyros Kollias, Sara L. Kroll, et al. 2017. “Hippocampal Shape Alterations Are Associated with Regional Aβ Load in Cognitively Normal Elderly Individuals.” European Journal of Neuroscience 45 (10): 1241–51. https://doi.org/10.1111/ejn.13408.
Schroeder, Clemens, et al. “Hippocampal Shape Alterations Are Associated with Regional Aβ Load in Cognitively Normal Elderly Individuals.” European Journal of Neuroscience, vol. 45, no. 10, May 2017, pp. 1241–51, https://doi.org/10.1111/ejn.13408.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.