Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals
Authors: Schroeder, Clemens
Park, Min Tae M.
Germann, Jürgen
Chakravarty, M. Mallar
Michels, Lars
Kollias, Spyros
Kroll, Sara L.
Buck, Alfred
Treyer, Valerie
Savaskan, Egemen
Unschuld, Paul G.
Nitsch, Roger M.
Kälin, Andrea M.
Hock, Christoph
Gietl, Anton F.
Leh, Sandra E.
et. al: No
DOI: 10.1111/ejn.13408
Published in: European Journal of Neuroscience
Volume(Issue): 45
Issue: 10
Page(s): 1241
Pages to: 1251
Issue Date: May-2017
Publisher / Ed. Institution: Wiley
ISSN: 0953-816X
Language: English
Subjects: Alzheimer's disease; Beta-amyloid; Hippocampal shape; Magnetic resonance imaging; Positron emission tomography; Aged; Amyloid beta-Peptide; Hippocampus; Human; Radiopharmaceuticals
Subject (DDC): 616.8: Neurology, diseases of nervous system
Abstract: Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11-C-Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (P < 0.05, FDR corrected), whereas volumes of the hippocampi and their subregions were not associated with cortical or regional PiB uptake (all P > 0.05, FDR corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical PiB uptake (P < 0.05, FDR corrected). Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Finance and Services
Appears in collections:Publikationen Finanzen & Services

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