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https://doi.org/10.21256/zhaw-20637| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons |
| Autor/-in: | Fitzli, Dora Stoeckli, Esther T. Kunz, Stefan Siribour, Kingsley Rader, Christoph Kunz, Beat Kozlov, Serguei V. Buchstaller, Andrea Lane, Robert P. Suter, Daniel M. Dreyer, William J. Sonderegger, Peter |
| et. al: | No |
| DOI: | 10.1083/jcb.149.4.951 10.21256/zhaw-20637 |
| Erschienen in: | Journal of Cell Biology |
| Band(Heft): | 149 |
| Heft: | 4 |
| Seite(n): | 951 |
| Seiten bis: | 968 |
| Erscheinungsdatum: | 15-Mai-2000 |
| Verlag / Hrsg. Institution: | Rockefeller University Press |
| ISSN: | 0021-9525 1540-8140 |
| Sprache: | Englisch |
| Schlagwörter: | Animals; Axons; Binding sites; Cell adhesion; Cell adhesion molecules; Chick embryo; Contactin 2; Growth cones; Multigene family; Neural pathways; Protein binding; Recombinant proteins; Spinal cord; Embryonic induction |
| Fachgebiet (DDC): | 571: Physiologie und verwandte Themen |
| Zusammenfassung: | An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elongation. In an in vitro assay, commissural axons grew preferentially on stripes coated with a mixture of NrCAM and NgCAM. This preference was abolished in the presence of anti-axonin-1 antibodies without a decrease in neurite length. Consistent with these findings, commissural axons in vivo only fail to extend along the longitudinal axis when both NrCAM and NgCAM interactions, but not when axonin-1 and NrCAM or axonin-1 and NgCAM interactions, are perturbed. Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/20637 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Rektorat und Ressorts |
| Organisationseinheit: | Generalsekretariat |
| Enthalten in den Sammlungen: | Publikationen Rektorat und Ressorts |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2000_Fitzli_etal_Direct-interaction-of-Axonin-1_JCB.pdf | 12.72 MB | Adobe PDF |  Öffnen/Anzeigen |
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Fitzli, D., Stoeckli, E. T., Kunz, S., Siribour, K., Rader, C., Kunz, B., Kozlov, S. V., Buchstaller, A., Lane, R. P., Suter, D. M., Dreyer, W. J., & Sonderegger, P. (2000). A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons. Journal of Cell Biology, 149(4), 951–968. https://doi.org/10.1083/jcb.149.4.951
Fitzli, D. et al. (2000) ‘A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons’, Journal of Cell Biology, 149(4), pp. 951–968. Available at: https://doi.org/10.1083/jcb.149.4.951.
D. Fitzli et al., “A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons,” Journal of Cell Biology, vol. 149, no. 4, pp. 951–968, May 2000, doi: 10.1083/jcb.149.4.951.
FITZLI, Dora, Esther T. STOECKLI, Stefan KUNZ, Kingsley SIRIBOUR, Christoph RADER, Beat KUNZ, Serguei V. KOZLOV, Andrea BUCHSTALLER, Robert P. LANE, Daniel M. SUTER, William J. DREYER und Peter SONDEREGGER, 2000. A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons. Journal of Cell Biology. 15 Mai 2000. Bd. 149, Nr. 4, S. 951–968. DOI 10.1083/jcb.149.4.951
Fitzli, Dora, Esther T. Stoeckli, Stefan Kunz, Kingsley Siribour, Christoph Rader, Beat Kunz, Serguei V. Kozlov, et al. 2000. “A Direct Interaction of Axonin-1 with Ngcam-Related Cell Adhesion Molecule (Nrcam) Results in Guidance, but Not Growth of Commissural Axons.” Journal of Cell Biology 149 (4): 951–68. https://doi.org/10.1083/jcb.149.4.951.
Fitzli, Dora, et al. “A Direct Interaction of Axonin-1 with Ngcam-Related Cell Adhesion Molecule (Nrcam) Results in Guidance, but Not Growth of Commissural Axons.” Journal of Cell Biology, vol. 149, no. 4, May 2000, pp. 951–68, https://doi.org/10.1083/jcb.149.4.951.
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