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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: A direct interaction of Axonin-1 with Ngcam-related cell adhesion molecule (Nrcam) results in guidance, but not growth of commissural axons
Authors: Fitzli, Dora
Stoeckli, Esther T.
Kunz, Stefan
Siribour, Kingsley
Rader, Christoph
Kunz, Beat
Kozlov, Serguei V.
Buchstaller, Andrea
Lane, Robert P.
Suter, Daniel M.
Dreyer, William J.
Sonderegger, Peter
et. al: No
DOI: 10.1083/jcb.149.4.951
Published in: Journal of Cell Biology
Volume(Issue): 149
Issue: 4
Pages: 951
Pages to: 968
Issue Date: 15-May-2000
Publisher / Ed. Institution: Rockefeller University Press
ISSN: 0021-9525
Language: English
Subjects: Animals; Axons; Binding sites; Cell adhesion; Cell adhesion molecules; Chick embryo; Contactin 2; Growth cones; Multigene family; Neural pathways; Protein binding; Recombinant proteins; Spinal cord; Embryonic induction
Subject (DDC): 571: Physiology and related subjects
Abstract: An interaction of growth cone axonin-1 with the floor-plate NgCAM-related cell adhesion molecule (NrCAM) was shown to play a crucial role in commissural axon guidance across the midline of the spinal cord. We now provide evidence that axonin-1 mediates a guidance signal without promoting axon elongation. In an in vitro assay, commissural axons grew preferentially on stripes coated with a mixture of NrCAM and NgCAM. This preference was abolished in the presence of anti-axonin-1 antibodies without a decrease in neurite length. Consistent with these findings, commissural axons in vivo only fail to extend along the longitudinal axis when both NrCAM and NgCAM interactions, but not when axonin-1 and NrCAM or axonin-1 and NgCAM interactions, are perturbed. Thus, we conclude that axonin-1 is involved in guidance of commissural axons without promoting their growth.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: President's Office
Organisational Unit: General Secretary's Office
Appears in Collections:Publikationen Rektorat und Ressorts

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