| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Directed evolution of carbon–hydrogen bond activating enzymes |
| Autor/-in: | Frey, Raphael Hayashi, Takahiro Buller, Rebecca |
| DOI: | 10.1016/j.copbio.2018.12.004 |
| Erschienen in: | Current Opinion in Biotechnology |
| Band(Heft): | 60 |
| Seite(n): | 29 |
| Seiten bis: | 38 |
| Erscheinungsdatum: | 2019 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 0958-1669 1879-0429 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 660.6: Biotechnologie |
| Zusammenfassung: | As industrial biocatalysis is maturing, access to enzymatic activities beyond chiral resolutions, asymmetric ketone reductions and reductive aminations is gradually becoming reality. Especially the utilization of carbon-hydrogen bond (C-H) activating enzymes is very attractive as they catalyze a variety of chemically extremely challenging transformations. Because of their intrinsic complexity, the use of these enzymes in manufacturing has been limited. However, recent advances in enzyme engineering and bioinformatics have led to activity improvements for native and non-native substrates, the introduction of new-to-nature chemistries and the identification of promising novel enzyme families. Looking forward, the use of automation and advanced computer algorithms will help to streamline the evolution process of C-H activating enzymes leading to more robust and active biocatalysts. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/16374 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Frey, R., Hayashi, T., & Buller, R. (2019). Directed evolution of carbon–hydrogen bond activating enzymes. Current Opinion in Biotechnology, 60, 29–38. https://doi.org/10.1016/j.copbio.2018.12.004
Frey, R., Hayashi, T. and Buller, R. (2019) ‘Directed evolution of carbon–hydrogen bond activating enzymes’, Current Opinion in Biotechnology, 60, pp. 29–38. Available at: https://doi.org/10.1016/j.copbio.2018.12.004.
R. Frey, T. Hayashi, and R. Buller, “Directed evolution of carbon–hydrogen bond activating enzymes,” Current Opinion in Biotechnology, vol. 60, pp. 29–38, 2019, doi: 10.1016/j.copbio.2018.12.004.
FREY, Raphael, Takahiro HAYASHI und Rebecca BULLER, 2019. Directed evolution of carbon–hydrogen bond activating enzymes. Current Opinion in Biotechnology. 2019. Bd. 60, S. 29–38. DOI 10.1016/j.copbio.2018.12.004
Frey, Raphael, Takahiro Hayashi, and Rebecca Buller. 2019. “Directed Evolution of Carbon–Hydrogen Bond Activating Enzymes.” Current Opinion in Biotechnology 60: 29–38. https://doi.org/10.1016/j.copbio.2018.12.004.
Frey, Raphael, et al. “Directed Evolution of Carbon–Hydrogen Bond Activating Enzymes.” Current Opinion in Biotechnology, vol. 60, 2019, pp. 29–38, https://doi.org/10.1016/j.copbio.2018.12.004.
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