Photostability of sennosides and their aglycones in solution

Meier, Nadja; Meier, Beat; Schenk, Alexander; Ziegler, Le Nhung; Peter, Samuel; Wolfram, Evelyn

doi:10.1002/pca.3308

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Photostability of sennosides and their aglycones in solution
Authors:	Meier, Nadja Meier, Beat Schenk, Alexander Ziegler, Le Nhung Peter, Samuel Wolfram, Evelyn
et. al:	No
DOI:	10.1002/pca.3308
Published in:	Phytochemical Analysis
Volume(Issue):	35
Issue:	3
Page(s):	521
Pages to:	529
Issue Date:	10-Jan-2024
Publisher / Ed. Institution:	Wiley
ISSN:	1099-1565 0958-0344
Language:	English
Subjects:	Senna alexandrina; Aglycone; Photostability; Rhein; Sennosides
Subject (DDC):	572: Biochemistry
Abstract:	Introduction: Sennosides are the main active constituents of the dried leaves and/or pods of Senna alexandrina Mill. that are used as laxatives. A hypothesis is that aglycones are formed during the degradation of sennosides. However, it is unknown, whether this happens under visible light exposure and how photosensitive sennosides behave in solution. Objectives: Pure anthraquinone glycosides were tested on their behaviour during sample preparation in the lab under visible light exposure in dependence on the instability of the solvent. Materials and methods: Samples before and after exposure were analysed using UHPLC with UV/Vis and MS detection. Results: Under visible light protection, the solutions were stable for 14 days at room temperature whereas a loss of 20%–60% was measured after 1 day of light exposure. The loss of sennosides due to degradation can be as fast as up to 2%–2.5% per hour, which might have a tremendous impact on phytochemical analysis results during the course of an analysis. The formation of aglycones was not observed in the degradation of sennosides and rhein-8-O-glucoside. Conclusion: Aglycones could not be found as a result of the forced degradation. The solutions of sennosides clearly need to be protected from light to obtain reliable analytical results, and light protection is a major point for the stability of liquid preparations.
URI:	https://digitalcollection.zhaw.ch/handle/11475/29642
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Meier, N., Meier, B., Schenk, A., Ziegler, L. N., Peter, S., & Wolfram, E. (2024). Photostability of sennosides and their aglycones in solution. Phytochemical Analysis, 35(3), 521–529. https://doi.org/10.1002/pca.3308

Meier, N. et al. (2024) ‘Photostability of sennosides and their aglycones in solution’, Phytochemical Analysis, 35(3), pp. 521–529. Available at: https://doi.org/10.1002/pca.3308.

N. Meier, B. Meier, A. Schenk, L. N. Ziegler, S. Peter, and E. Wolfram, “Photostability of sennosides and their aglycones in solution,” Phytochemical Analysis, vol. 35, no. 3, pp. 521–529, Jan. 2024, doi: 10.1002/pca.3308.

MEIER, Nadja, Beat MEIER, Alexander SCHENK, Le Nhung ZIEGLER, Samuel PETER und Evelyn WOLFRAM, 2024. Photostability of sennosides and their aglycones in solution. Phytochemical Analysis. 10 Januar 2024. Bd. 35, Nr. 3, S. 521–529. DOI 10.1002/pca.3308

Meier, Nadja, Beat Meier, Alexander Schenk, Le Nhung Ziegler, Samuel Peter, and Evelyn Wolfram. 2024. “Photostability of Sennosides and Their Aglycones in Solution.” Phytochemical Analysis 35 (3): 521–29. https://doi.org/10.1002/pca.3308.

Meier, Nadja, et al. “Photostability of Sennosides and Their Aglycones in Solution.” Phytochemical Analysis, vol. 35, no. 3, Jan. 2024, pp. 521–29, https://doi.org/10.1002/pca.3308.