| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | From nature to industry : harnessing enzymes for biocatalysis |
| Autor/-in: | Buller, R. Lutz, S. Kazlauskas, R. J. Snajdrova, R. Moore, J. C. Bornscheuer, U. T. |
| et. al: | No |
| DOI: | 10.1126/science.adh8615 |
| Erschienen in: | Science |
| Band(Heft): | 382 |
| Heft: | 6673 |
| Seite(n): | eadh8615 |
| Erscheinungsdatum: | 24-Nov-2023 |
| Verlag / Hrsg. Institution: | American Association for the Advancement of Science |
| ISSN: | 0036-8075 1095-9203 |
| Sprache: | Englisch |
| Schlagwörter: | Methanol; Technology; Substrate specificity; Biocatalysis; Enzyme; Protein engineering |
| Fachgebiet (DDC): | 660.6: Biotechnologie |
| Zusammenfassung: | Biocatalysis harnesses enzymes to make valuable products. This green technology is used in countless applications from bench scale to industrial production and allows practitioners to access complex organic molecules, often with fewer synthetic steps and reduced waste. The last decade has seen an explosion in the development of experimental and computational tools to tailor enzymatic properties, equipping enzyme engineers with the ability to create biocatalysts that perform reactions not present in nature. By using (chemo)-enzymatic synthesis routes or orchestrating intricate enzyme cascades, scientists can synthesize elaborate targets ranging from DNA and complex pharmaceuticals to starch made in vitro from CO2-derived methanol. In addition, new chemistries have emerged through the combination of biocatalysis with transition metal catalysis, photocatalysis, and electrocatalysis. This review highlights recent key developments, identifies current limitations, and provides a future prospect for this rapidly developing technology. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/29457 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
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Buller, R., Lutz, S., Kazlauskas, R. J., Snajdrova, R., Moore, J. C., & Bornscheuer, U. T. (2023). From nature to industry : harnessing enzymes for biocatalysis. Science, 382(6673), eadh8615. https://doi.org/10.1126/science.adh8615
Buller, R. et al. (2023) ‘From nature to industry : harnessing enzymes for biocatalysis’, Science, 382(6673), p. eadh8615. Available at: https://doi.org/10.1126/science.adh8615.
R. Buller, S. Lutz, R. J. Kazlauskas, R. Snajdrova, J. C. Moore, and U. T. Bornscheuer, “From nature to industry : harnessing enzymes for biocatalysis,” Science, vol. 382, no. 6673, p. eadh8615, Nov. 2023, doi: 10.1126/science.adh8615.
BULLER, R., S. LUTZ, R. J. KAZLAUSKAS, R. SNAJDROVA, J. C. MOORE und U. T. BORNSCHEUER, 2023. From nature to industry : harnessing enzymes for biocatalysis. Science. 24 November 2023. Bd. 382, Nr. 6673, S. eadh8615. DOI 10.1126/science.adh8615
Buller, R., S. Lutz, R. J. Kazlauskas, R. Snajdrova, J. C. Moore, and U. T. Bornscheuer. 2023. “From Nature to Industry : Harnessing Enzymes for Biocatalysis.” Science 382 (6673): eadh8615. https://doi.org/10.1126/science.adh8615.
Buller, R., et al. “From Nature to Industry : Harnessing Enzymes for Biocatalysis.” Science, vol. 382, no. 6673, Nov. 2023, p. eadh8615, https://doi.org/10.1126/science.adh8615.
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