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https://doi.org/10.21256/zhaw-29305| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Halogenases for the synthesis of small molecules |
| Autor/-in: | Hegarty, Eimear Büchler, Johannes Buller, Rebecca M. |
| et. al: | No |
| DOI: | 10.1016/j.cogsc.2023.100784 10.21256/zhaw-29305 |
| Erschienen in: | Current Opinion in Green and Sustainable Chemistry |
| Band(Heft): | 41 |
| Heft: | 100784 |
| Erscheinungsdatum: | Jun-2023 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 2452-2236 |
| Sprache: | Englisch |
| Schlagwörter: | Fe(II)/a-ketoglutaratedependenthalogenases; Flavin-dependent halogenase; Late-stage functionalization; Enzyme engineering; C–H activation; Biocatalysis |
| Fachgebiet (DDC): | 540: Chemie |
| Zusammenfassung: | Enzymatic halogenation is a rapidly developing tool in the synthetic chemist's toolbox. Utilizing oxygen, halide salts and operating at ambient temperatures in aqueous media, halogenating enzymes, particularly flavin- or Fe(II)/α-ketoglutarate dependent halogenases, allow the regio- and stereoselective installation of halogen atoms to yield valuable building blocks and uniquely derivatized complex molecules, including natural products. Apart from modulating the physico-chemical properties of molecules and, in consequence, their biological activity, halogen atoms can also serve as chemical linchpins for further derivatization of the molecular scaffold, for example in chemo-enzymatic cascades. Thanks to rapid advances in bioinformatic enzyme sourcing, biosynthetic pathway elucidation and enzyme engineering strategies, the palette of enzymatically produced halogenated structures is constantly growing. In addition, successful studies to improve catalytic performance of the halogenation biocatalysts are boding well for industrial applications. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/29305 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2023_Hegarty-Buechler-Buller_Halogenases-for-the-synthesis-of-small-molecules.pdf | 2.59 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Hegarty, E., Büchler, J., & Buller, R. M. (2023). Halogenases for the synthesis of small molecules. Current Opinion in Green and Sustainable Chemistry, 41(100784). https://doi.org/10.1016/j.cogsc.2023.100784
Hegarty, E., Büchler, J. and Buller, R.M. (2023) ‘Halogenases for the synthesis of small molecules’, Current Opinion in Green and Sustainable Chemistry, 41(100784). Available at: https://doi.org/10.1016/j.cogsc.2023.100784.
E. Hegarty, J. Büchler, and R. M. Buller, “Halogenases for the synthesis of small molecules,” Current Opinion in Green and Sustainable Chemistry, vol. 41, no. 100784, Jun. 2023, doi: 10.1016/j.cogsc.2023.100784.
HEGARTY, Eimear, Johannes BÜCHLER und Rebecca M. BULLER, 2023. Halogenases for the synthesis of small molecules. Current Opinion in Green and Sustainable Chemistry. Juni 2023. Bd. 41, Nr. 100784. DOI 10.1016/j.cogsc.2023.100784
Hegarty, Eimear, Johannes Büchler, and Rebecca M. Buller. 2023. “Halogenases for the Synthesis of Small Molecules.” Current Opinion in Green and Sustainable Chemistry 41 (100784). https://doi.org/10.1016/j.cogsc.2023.100784.
Hegarty, Eimear, et al. “Halogenases for the Synthesis of Small Molecules.” Current Opinion in Green and Sustainable Chemistry, vol. 41, no. 100784, June 2023, https://doi.org/10.1016/j.cogsc.2023.100784.
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