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https://doi.org/10.21256/zhaw-28453| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Effects of psychotherapy on glutamatergic neurotransmission |
| Autor/-in: | Wade-Bohleber, Laura Zoelch, Niklaus Lehmann, Mick Ernst, Jutta Richter, André Seifritz, Erich Boeker, Heinz Grimm, Simone |
| et. al: | No |
| DOI: | 10.1159/000530312 10.21256/zhaw-28453 |
| Erschienen in: | Neuropsychobiology |
| Band(Heft): | 82 |
| Heft: | 4 |
| Seite(n): | 203 |
| Seiten bis: | 209 |
| Erscheinungsdatum: | 15-Jun-2023 |
| Verlag / Hrsg. Institution: | Karger |
| ISSN: | 0302-282X 1423-0224 |
| Sprache: | Englisch |
| Schlagwörter: | Depression; Glutamate; Glutamine; Proton magnetic resonance spectroscopy; Psychotherapy |
| Fachgebiet (DDC): | 616.89: Psychische Störungen, klinische Psychologie und Psychiatrie |
| Zusammenfassung: | Introduction: Psychodynamic psychotherapy is an effective and widely used treatment for major depressive disorder (MDD); however, little is known about neurobiological changes associated with induced symptom improvement. Methods: Proton magnetic resonance spectroscopy with a two-dimensional J-resolved sequence served to test the relationship between glutamate (Glu) and glutamine (Gln) levels, measured separately in pregenual anterior cingulate cortex (pgACC) and the anterior midcingulate cortex (aMCC) as a control region, with change in depression symptoms after 6 months of weekly psychodynamic psychotherapy sessions in MDD patients. Depressed (N = 45) and healthy (N = 30) subjects participated in a baseline proton magnetic resonance spectroscopy measurement and a subgroup of MDD subjects (N = 21) then received once-a-week psychodynamic psychotherapy and participated in a second proton magnetic resonance spectroscopy measurement after 6 months. Change in depression symptoms was assessed using the Hamilton Depression Rating Scale (HAMD). Results: Higher pretreatment pgACC Gln concentrations in MDD patients compared to healthy controls were associated with symptom severity. Patients and controls did not differ regarding Gln levels in aMCC nor regarding Glu levels in both regions. The association of pgACC Gln concentration and severity of depressive symptoms was reversed after 6 months of psychotherapy in MDD subjects. Regarding Gln in aMCC as well as Glu in both regions, there were no significant associations with improvement of depressive symptoms in the course of psychotherapy. Discussion: Findings indicate specific regional effects of psychodynamic psychotherapy on glutamatergic neurotransmission and thereby highlight the key role of the pgACC in both depression pathophysiology and recovery. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/28453 |
| Zugehörige Forschungsdaten: | https://doi.org/10.48573/kfpv-pt95 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Angewandte Psychologie |
| Organisationseinheit: | Psychologisches Institut (PI) |
| Enthalten in den Sammlungen: | Publikationen Angewandte Psychologie |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2023_WadeBohleber-etal_Effects-of-psychotherapy-on-glutamatergic-neurotransmission.pdf | 669.41 kB | Adobe PDF |  Öffnen/Anzeigen |
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Wade-Bohleber, L., Zoelch, N., Lehmann, M., Ernst, J., Richter, A., Seifritz, E., Boeker, H., & Grimm, S. (2023). Effects of psychotherapy on glutamatergic neurotransmission. Neuropsychobiology, 82(4), 203–209. https://doi.org/10.1159/000530312
Wade-Bohleber, L. et al. (2023) ‘Effects of psychotherapy on glutamatergic neurotransmission’, Neuropsychobiology, 82(4), pp. 203–209. Available at: https://doi.org/10.1159/000530312.
L. Wade-Bohleber et al., “Effects of psychotherapy on glutamatergic neurotransmission,” Neuropsychobiology, vol. 82, no. 4, pp. 203–209, Jun. 2023, doi: 10.1159/000530312.
WADE-BOHLEBER, Laura, Niklaus ZOELCH, Mick LEHMANN, Jutta ERNST, André RICHTER, Erich SEIFRITZ, Heinz BOEKER und Simone GRIMM, 2023. Effects of psychotherapy on glutamatergic neurotransmission. Neuropsychobiology. 15 Juni 2023. Bd. 82, Nr. 4, S. 203–209. DOI 10.1159/000530312
Wade-Bohleber, Laura, Niklaus Zoelch, Mick Lehmann, Jutta Ernst, André Richter, Erich Seifritz, Heinz Boeker, and Simone Grimm. 2023. “Effects of Psychotherapy on Glutamatergic Neurotransmission.” Neuropsychobiology 82 (4): 203–9. https://doi.org/10.1159/000530312.
Wade-Bohleber, Laura, et al. “Effects of Psychotherapy on Glutamatergic Neurotransmission.” Neuropsychobiology, vol. 82, no. 4, June 2023, pp. 203–9, https://doi.org/10.1159/000530312.
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