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https://doi.org/10.21256/zhaw-25988| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Methadone does not potentiate the effect of doxorubicin in canine tumour cell lines |
| Autor/-in: | Cueni, Claudia Nytko, Katarzyna J. Thumser-Henner, Pauline Weyland, Mathias S. Rohrer Bley, Carla |
| et. al: | No |
| DOI: | 10.1002/vms3.266 10.21256/zhaw-25988 |
| Erschienen in: | Veterinary Medicine and Science |
| Band(Heft): | 6 |
| Heft: | 3 |
| Seite(n): | 283 |
| Seiten bis: | 289 |
| Erscheinungsdatum: | 2020 |
| Verlag / Hrsg. Institution: | Wiley |
| ISSN: | 2053-1095 2053-1095 |
| Sprache: | Englisch |
| Schlagwörter: | Buprenorphine; Cancer; Dog; Flow cytometry; Opioid receptor; µ-receptor; Animal; Antineoplastic agent; Buprenorphine; Cell line, tumor; Cell proliferation; Doxorubicin; Methadone |
| Fachgebiet (DDC): | 630: Landwirtschaft |
| Zusammenfassung: | Opioid receptor activation was shown to enhance the efficacy of anti-neoplastic drugs in several human cancer cell lines. In these cell lines, doxorubicin increased the number of opioid receptors and methadone concurrently enhanced cellular doxorubicin uptake. Triggered through lay press and media, animal owners started to challenge veterinary oncologists with questions about methadone use in anti-cancer therapy. Especially in veterinary medicine, where side effects of chemotherapy are tolerated to a lesser extent and hence smaller doses are given, agents potentiating chemotherapeutic agents would be an optimal approach to treatment. Canine transitional cell carcinoma cells (TCC, K9TCC), canine osteosarcoma cells (OSA, Abrams) and canine hemangiosarcoma cells (HSA, DAL-4) were incubated with different combinations of methadone, buprenorphine and doxorubicin, in order to test inhibition of cell proliferation. Opioid receptor density was assessed with fluorescence-activated cell sorting in drug native and doxorubicin pretreated cells. In TCC and OSA cell lines opioid receptor density increased after doxorubicin pretreatment. In combination treatment, however, we did not find significant potentiation of doxorubicin's inhibitory effect on proliferation in these cell lines. Neither was there a significant increase of the effect of doxorubicin when the opioids were added 24 hr before doxorubicin. Hence, we could not confirm the hypothesis that opioids increase the anti-proliferative effect of the anti-neoplastic drug doxorubicin in any of these canine tumour cell lines. The lack of effect on a cellular level does not warrant a clinical approach to use opioids together with doxorubicin in dogs with cancer. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/25988 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | School of Engineering |
| Organisationseinheit: | Institut für Angewandte Mathematik und Physik (IAMP) |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2020_Cueni-etal_Methadone-does-not-potentiate-the-effect-of-doxorubicin_Vet-Med-Sci.pdf | 589.89 kB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Cueni, C., Nytko, K. J., Thumser-Henner, P., Weyland, M. S., & Rohrer Bley, C. (2020). Methadone does not potentiate the effect of doxorubicin in canine tumour cell lines. Veterinary Medicine and Science, 6(3), 283–289. https://doi.org/10.1002/vms3.266
Cueni, C. et al. (2020) ‘Methadone does not potentiate the effect of doxorubicin in canine tumour cell lines’, Veterinary Medicine and Science, 6(3), pp. 283–289. Available at: https://doi.org/10.1002/vms3.266.
C. Cueni, K. J. Nytko, P. Thumser-Henner, M. S. Weyland, and C. Rohrer Bley, “Methadone does not potentiate the effect of doxorubicin in canine tumour cell lines,” Veterinary Medicine and Science, vol. 6, no. 3, pp. 283–289, 2020, doi: 10.1002/vms3.266.
CUENI, Claudia, Katarzyna J. NYTKO, Pauline THUMSER-HENNER, Mathias S. WEYLAND und Carla ROHRER BLEY, 2020. Methadone does not potentiate the effect of doxorubicin in canine tumour cell lines. Veterinary Medicine and Science. 2020. Bd. 6, Nr. 3, S. 283–289. DOI 10.1002/vms3.266
Cueni, Claudia, Katarzyna J. Nytko, Pauline Thumser-Henner, Mathias S. Weyland, and Carla Rohrer Bley. 2020. “Methadone Does Not Potentiate the Effect of Doxorubicin in Canine Tumour Cell Lines.” Veterinary Medicine and Science 6 (3): 283–89. https://doi.org/10.1002/vms3.266.
Cueni, Claudia, et al. “Methadone Does Not Potentiate the Effect of Doxorubicin in Canine Tumour Cell Lines.” Veterinary Medicine and Science, vol. 6, no. 3, 2020, pp. 283–89, https://doi.org/10.1002/vms3.266.
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