| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Development of a diffusion-weighed mathematical model for intradermal drainage quantification |
| Autor/-in: | Kirsch, Christoph Fehr, Daniel Babity, Samuel Polomska, Anna Detmar, Michael Bonmarin, Mathias Brambilla, Davide |
| et. al: | No |
| DOI: | 10.1007/s13346-021-01114-1 |
| Erschienen in: | Drug Delivery and Translational Research |
| Band(Heft): | 12 |
| Heft: | 4 |
| Seite(n): | 897 |
| Seiten bis: | 905 |
| Erscheinungsdatum: | 2022 |
| Verlag / Hrsg. Institution: | Springer |
| ISSN: | 2190-393X 2190-3948 |
| Sprache: | Englisch |
| Schlagwörter: | Lymphatic drainage; Fluorescence; Diffusion; Intradermal administration |
| Fachgebiet (DDC): | 510: Mathematik |
| Zusammenfassung: | The quantitative assessment of lymphatic dermal clearance using NIR fluorescent tracers is particularly important for the early diagnosis of several potential disabling diseases. Currently, half-life values are computed using a mono-exponential mathematical model, neglecting diffusion of the tracer within the dermis after injection. The size and position of the region of interest are subjectively manually selected around the point of injection on the skin surface where the fluorescence signal intensity is averaged, neglecting any spatial information contained in the image. In this study we present and test a novel mathematical model allowing the objective quantification of dermal clearance, taking into consideration potential dermal diffusion. With only two parameters, this “clearance-diffusion” model is simple enough to be applied in a variety of settings and requires almost no prior information about the system. We demonstrate that if dermal diffusion is low, the mono-exponential approach is suitable but still lacking objectivity. However, if dermal diffusion is substantial, the clearance-diffusion model is superior and allows the accurate calculation of half-life values. |
| Weitere Angaben: | Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch) |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/24468 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | School of Engineering |
| Organisationseinheit: | Institute of Computational Physics (ICP) |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
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Kirsch, C., Fehr, D., Babity, S., Polomska, A., Detmar, M., Bonmarin, M., & Brambilla, D. (2022). Development of a diffusion-weighed mathematical model for intradermal drainage quantification. Drug Delivery and Translational Research, 12(4), 897–905. https://doi.org/10.1007/s13346-021-01114-1
Kirsch, C. et al. (2022) ‘Development of a diffusion-weighed mathematical model for intradermal drainage quantification’, Drug Delivery and Translational Research, 12(4), pp. 897–905. Available at: https://doi.org/10.1007/s13346-021-01114-1.
C. Kirsch et al., “Development of a diffusion-weighed mathematical model for intradermal drainage quantification,” Drug Delivery and Translational Research, vol. 12, no. 4, pp. 897–905, 2022, doi: 10.1007/s13346-021-01114-1.
KIRSCH, Christoph, Daniel FEHR, Samuel BABITY, Anna POLOMSKA, Michael DETMAR, Mathias BONMARIN und Davide BRAMBILLA, 2022. Development of a diffusion-weighed mathematical model for intradermal drainage quantification. Drug Delivery and Translational Research. 2022. Bd. 12, Nr. 4, S. 897–905. DOI 10.1007/s13346-021-01114-1
Kirsch, Christoph, Daniel Fehr, Samuel Babity, Anna Polomska, Michael Detmar, Mathias Bonmarin, and Davide Brambilla. 2022. “Development of a Diffusion-Weighed Mathematical Model for Intradermal Drainage Quantification.” Drug Delivery and Translational Research 12 (4): 897–905. https://doi.org/10.1007/s13346-021-01114-1.
Kirsch, Christoph, et al. “Development of a Diffusion-Weighed Mathematical Model for Intradermal Drainage Quantification.” Drug Delivery and Translational Research, vol. 12, no. 4, 2022, pp. 897–905, https://doi.org/10.1007/s13346-021-01114-1.
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