Publikationstyp: Beitrag in wissenschaftlicher Zeitschrift
Art der Begutachtung: Peer review (Publikation)
Titel: Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases
Autor/-in: Natsch, Andreas
Kern, Susanne
Corbi, Elise
Pérès, Christophe
Nägelin, Marco
Leijs, Hans
von Strien, Michel
Calandra, Michael J.
Wang, Ying
et. al: No
DOI: 10.1002/ffj.3451
Erschienen in: Flavour and Fragrance Journal
Band(Heft): 33
Heft: 4
Seite(n): 322
Seiten bis: 330
Erscheinungsdatum: 22-Apr-2018
Verlag / Hrsg. Institution: Wiley
ISSN: 0882-5734
1099-1026
Sprache: Englisch
Schlagwörter: Cream; GC-MS; LC-MS; Lotion; Quantification; Skin allergy; Terpene hydroperoxides
Fachgebiet (DDC): 660: Technische Chemie
Zusammenfassung: The fragrant terpenes limonene and linalool can form skin-sensitizing hydroperoxides (HPs) upon prolonged exposure to air. Sources of exposure of consumers to sensitizing doses of HPs have not been identified, and it is not clear whether fragranced products are a relevant source. Previously this question was addressed via analytical studies on fine fragrances; however, linalool and limonene are widely used in different consumer products, especially in other leave-on toiletries. Hence, analytical methods also need to be able to detect potential HPs in more complex consumer product matrices. Here we applied different simple extraction methods and a toolbox of analytical methods to creams and lotions. Blinded samples of a commercial skin cream and a body lotion were spiked with four different HPs at different doses. Five laboratories analysed the samples with a method based on HP reduction in the sample, followed by Extrelut® NT extraction and GC-MS to quantify the formed alcohols. This method found an average recovery of spiked levels of 80–105%, with a relative standard deviation between laboratories of 11–25% in samples spiked with 100–200 μg g−1. Quantification was also possible in samples spiked with 20–50 μg mL−1, with a relative standard deviation between laboratories of 11–38%. Thus, this method can indirectly detect low levels of HPs in complex bases. In parallel, the same samples were analysed with three LC-based methods directly detecting the parent HPs: LC coupled with chemiluminescence, LC-Q-TOF-MS, and LC-orbitrap-MS. On average, the different analytes were detected with a recovery of 80–143%. No HPs were detected in the non-spiked products, despite the fact that they do contain linalool and limonene. Results of these studies indicate that consumer exposure can now be studied routinely in different product types as the required methods are ready for roll-out.
URI: https://digitalcollection.zhaw.ch/handle/11475/23921
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): Lizenz gemäss Verlagsvertrag
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Chemie und Biotechnologie (ICBT)
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

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Natsch, A., Kern, S., Corbi, E., Pérès, C., Nägelin, M., Leijs, H., von Strien, M., Calandra, M. J., & Wang, Y. (2018). Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases. Flavour and Fragrance Journal, 33(4), 322–330. https://doi.org/10.1002/ffj.3451
Natsch, A. et al. (2018) ‘Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases’, Flavour and Fragrance Journal, 33(4), pp. 322–330. Available at: https://doi.org/10.1002/ffj.3451.
A. Natsch et al., “Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases,” Flavour and Fragrance Journal, vol. 33, no. 4, pp. 322–330, Apr. 2018, doi: 10.1002/ffj.3451.
NATSCH, Andreas, Susanne KERN, Elise CORBI, Christophe PÉRÈS, Marco NÄGELIN, Hans LEIJS, Michel VON STRIEN, Michael J. CALANDRA und Ying WANG, 2018. Interlaboratory evaluation of methods to quantify skin-sensitizing hydroperoxides of limonene and linalool (II) : analysis in cosmetic bases. Flavour and Fragrance Journal. 22 April 2018. Bd. 33, Nr. 4, S. 322–330. DOI 10.1002/ffj.3451
Natsch, Andreas, Susanne Kern, Elise Corbi, Christophe Pérès, Marco Nägelin, Hans Leijs, Michel von Strien, Michael J. Calandra, and Ying Wang. 2018. “Interlaboratory Evaluation of Methods to Quantify Skin-Sensitizing Hydroperoxides of Limonene and Linalool (II) : Analysis in Cosmetic Bases.” Flavour and Fragrance Journal 33 (4): 322–30. https://doi.org/10.1002/ffj.3451.
Natsch, Andreas, et al. “Interlaboratory Evaluation of Methods to Quantify Skin-Sensitizing Hydroperoxides of Limonene and Linalool (II) : Analysis in Cosmetic Bases.” Flavour and Fragrance Journal, vol. 33, no. 4, Apr. 2018, pp. 322–30, https://doi.org/10.1002/ffj.3451.


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