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https://doi.org/10.21256/zhaw-20252| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems |
| Autor/-in: | Weyland, Mathias S. Thumser-Henner, Pauline Nytko, Katarzyna J. Rohrer Bley, Carla Ulzega, Simone Petri-Fink, Alke Lattuada, Marco Füchslin, Rudolf Marcel Scheidegger, Stephan |
| et. al: | No |
| DOI: | 10.1155/2020/5972594 10.21256/zhaw-20252 |
| Erschienen in: | Computational and Mathematical Methods in Medicine |
| Band(Heft): | 2020 |
| Erscheinungsdatum: | 15-Sep-2020 |
| Verlag / Hrsg. Institution: | Hindawi |
| ISSN: | 1748-670X 1748-6718 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 572: Biochemie |
| Zusammenfassung: | In this work, a method is established to calibrate a model that describes the basic dynamics of DNA damage and repair. The model can be used to extend planning for radiotherapy and hyperthermia in order to include the biological effects. In contrast to ``syntactic'' models (e.g. describing molecular kinetics), the model used here describes radiobiological semantics, resulting in a more powerful model but also in a far more challenging calibration. Model calibration is attempted from clonogenic assay data (doses of 0 -- 6 Gy) and from time-resolved comet assay data obtained within 6~h after irradiation with 6~Gy. It is demonstrated that either of those two sources of information alone is insufficient for successful model calibration, and that both sources of information combined in a holistic approach are necessary to find viable model parameters. Approximate Bayesian Computation (ABC) with simulated annealing is used for parameter search, revealing two aspects that are beneficial to resolving the calibration problem: (1) assessing posterior parameter distributions instead of point-estimates; (2) combining calibration runs from different assays by joining posterior distributions instead of running a single calibration run with a combined, computationally very expensive objective function. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/20252 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | School of Engineering Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Angewandte Mathematik und Physik (IAMP) Institut für Computational Life Sciences (ICLS) |
| Publiziert im Rahmen des ZHAW-Projekts: | Dynamic Thermal Dosimetric Concept for Evaluating Synergistic Effect of Combined Hyperthermia-Radiotherapy (RT-HT) |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2020_Weyland_Holistic_View_on_Cell_Survival_and_DNA_Damage_Computational_and_Mathematical_Methods_in_Medicine.pdf | 2.18 MB | Adobe PDF |  Öffnen/Anzeigen |
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Weyland, M. S., Thumser-Henner, P., Nytko, K. J., Rohrer Bley, C., Ulzega, S., Petri-Fink, A., Lattuada, M., Füchslin, R. M., & Scheidegger, S. (2020). Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems. Computational and Mathematical Methods in Medicine, 2020. https://doi.org/10.1155/2020/5972594
Weyland, M.S. et al. (2020) ‘Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems’, Computational and Mathematical Methods in Medicine, 2020. Available at: https://doi.org/10.1155/2020/5972594.
M. S. Weyland et al., “Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems,” Computational and Mathematical Methods in Medicine, vol. 2020, Sep. 2020, doi: 10.1155/2020/5972594.
WEYLAND, Mathias S., Pauline THUMSER-HENNER, Katarzyna J. NYTKO, Carla ROHRER BLEY, Simone ULZEGA, Alke PETRI-FINK, Marco LATTUADA, Rudolf Marcel FÜCHSLIN und Stephan SCHEIDEGGER, 2020. Holistic view on cell survival and DNA damage : how model-based data analysis supports exploration of dynamics in biological systems. Computational and Mathematical Methods in Medicine. 15 September 2020. Bd. 2020. DOI 10.1155/2020/5972594
Weyland, Mathias S., Pauline Thumser-Henner, Katarzyna J. Nytko, Carla Rohrer Bley, Simone Ulzega, Alke Petri-Fink, Marco Lattuada, Rudolf Marcel Füchslin, and Stephan Scheidegger. 2020. “Holistic View on Cell Survival and DNA Damage : How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems.” Computational and Mathematical Methods in Medicine 2020 (September). https://doi.org/10.1155/2020/5972594.
Weyland, Mathias S., et al. “Holistic View on Cell Survival and DNA Damage : How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems.” Computational and Mathematical Methods in Medicine, vol. 2020, Sept. 2020, https://doi.org/10.1155/2020/5972594.
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