Maternal age at delivery, lung function and asthma in offspring : a population-based survey

Gómez Real, Francisco; Burgess, John A.; Villani, Simona; Dratva, Julia; Heinrich, Joachim; Janson, Christer; Jarvis, Debbie; Koplin, Jennifer; Leynaert, Bénédicte; Lodge, Caroline; Lærum, Birger N.; Matheson, Melanie C.; Norbäck, Dan; Omenaas, Ernst R.; Skulstad, Svein M.; Sunyer, Jordi; Dharmage, Shyamali C.; Svanes, Cecilie

doi:10.1183/13993003.01611-2016

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Maternal age at delivery, lung function and asthma in offspring : a population-based survey
Authors:	Gómez Real, Francisco Burgess, John A. Villani, Simona Dratva, Julia Heinrich, Joachim Janson, Christer Jarvis, Debbie Koplin, Jennifer Leynaert, Bénédicte Lodge, Caroline Lærum, Birger N. Matheson, Melanie C. Norbäck, Dan Omenaas, Ernst R. Skulstad, Svein M. Sunyer, Jordi Dharmage, Shyamali C. Svanes, Cecilie
DOI:	10.1183/13993003.01611-2016
Published in:	The European Respiratory Journal
Volume(Issue):	51
Issue:	1601611
Issue Date:	2018
Publisher / Ed. Institution:	European Respiratory Society
ISSN:	0903-1936 1399-3003
Language:	English
Subjects:	Adolescent; Adult; Asthma; Female; Forced expiratory volume; Health survey; Human; Immunoglobulin E; Internationality; Linear model; Logistic model; Lung; Male; Middle aged; Pregnancy; Prenatal exposure delayed effect; Sex factor; Smoking; Young adult; Maternal age
Subject (DDC):	616: Internal medicine and diseases
Abstract:	There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry.Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (ptrend 0.025) than in males (ptrend 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (pinteraction 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors.Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.
URI:	https://digitalcollection.zhaw.ch/handle/11475/17251
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Health Sciences
Organisational Unit:	Institute of Public Health (IPH)
Appears in collections:	Publikationen Gesundheit

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Gómez Real, F., Burgess, J. A., Villani, S., Dratva, J., Heinrich, J., Janson, C., Jarvis, D., Koplin, J., Leynaert, B., Lodge, C., Lærum, B. N., Matheson, M. C., Norbäck, D., Omenaas, E. R., Skulstad, S. M., Sunyer, J., Dharmage, S. C., & Svanes, C. (2018). Maternal age at delivery, lung function and asthma in offspring : a population-based survey. The European Respiratory Journal, 51(1601611). https://doi.org/10.1183/13993003.01611-2016

Gómez Real, F. et al. (2018) ‘Maternal age at delivery, lung function and asthma in offspring : a population-based survey’, The European Respiratory Journal, 51(1601611). Available at: https://doi.org/10.1183/13993003.01611-2016.

F. Gómez Real et al., “Maternal age at delivery, lung function and asthma in offspring : a population-based survey,” The European Respiratory Journal, vol. 51, no. 1601611, 2018, doi: 10.1183/13993003.01611-2016.

GÓMEZ REAL, Francisco, John A. BURGESS, Simona VILLANI, Julia DRATVA, Joachim HEINRICH, Christer JANSON, Debbie JARVIS, Jennifer KOPLIN, Bénédicte LEYNAERT, Caroline LODGE, Birger N. LÆRUM, Melanie C. MATHESON, Dan NORBÄCK, Ernst R. OMENAAS, Svein M. SKULSTAD, Jordi SUNYER, Shyamali C. DHARMAGE und Cecilie SVANES, 2018. Maternal age at delivery, lung function and asthma in offspring : a population-based survey. The European Respiratory Journal. 2018. Bd. 51, Nr. 1601611. DOI 10.1183/13993003.01611-2016

Gómez Real, Francisco, John A. Burgess, Simona Villani, Julia Dratva, Joachim Heinrich, Christer Janson, Debbie Jarvis, et al. 2018. “Maternal Age at Delivery, Lung Function and Asthma in Offspring : A Population-Based Survey.” The European Respiratory Journal 51 (1601611). https://doi.org/10.1183/13993003.01611-2016.

Gómez Real, Francisco, et al. “Maternal Age at Delivery, Lung Function and Asthma in Offspring : A Population-Based Survey.” The European Respiratory Journal, vol. 51, no. 1601611, 2018, https://doi.org/10.1183/13993003.01611-2016.