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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-14456
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dc.contributor.authorAccordini, Simone-
dc.contributor.authorCalciano, Lucia-
dc.contributor.authorJohannessen, Ane-
dc.contributor.authorPortas, Laura-
dc.contributor.authorBenediktsdóttir, Bryndis-
dc.contributor.authorBertelsen, Randi Jacobsen-
dc.contributor.authorBråbäck, Lennart-
dc.contributor.authorCarsin, Anne-Elie-
dc.contributor.authorDharmage, Shyamali C-
dc.contributor.authorDratva, Julia-
dc.contributor.authorForsberg, Bertil-
dc.contributor.authorGomez Real, Francisco-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorHolloway, John W-
dc.contributor.authorHolm, Mathias-
dc.contributor.authorJanson, Christer-
dc.contributor.authorJögi, Rain-
dc.contributor.authorLeynaert, Bénédicte-
dc.contributor.authorMalinovschi, Andrei-
dc.contributor.authorMarcon, Alessandro-
dc.contributor.authorMartínez-Moratalla Rovira, Jesús-
dc.contributor.authorRaherison, Chantal-
dc.contributor.authorSánchez-Ramos, José Luis-
dc.contributor.authorSchlünssen, Vivi-
dc.contributor.authorBono, Roberto-
dc.contributor.authorCorsico, Angelo G-
dc.contributor.authorDemoly, Pascal-
dc.contributor.authorDorado Arenas, Sandra-
dc.contributor.authorNowak, Dennis-
dc.contributor.authorPin, Isabelle-
dc.contributor.authorWeyler, Joost-
dc.contributor.authorJarvis, Deborah-
dc.contributor.authorSvanes, Cecilie-
dc.date.accessioned2019-01-16T15:20:48Z-
dc.date.available2019-01-16T15:20:48Z-
dc.date.issued2018-
dc.identifier.issn0300-5771de_CH
dc.identifier.issn1464-3685de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/14456-
dc.description.abstractBackground: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.de_CH
dc.language.isoende_CH
dc.publisherOxford University Pressde_CH
dc.relation.ispartofInternational Journal of Epidemiologyde_CH
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/de_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleA three-generation study on the association of tobacco smoking with asthmade_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Public Health (IPH)de_CH
dc.identifier.doi10.1093/ije/dyy031de_CH
dc.identifier.doi10.21256/zhaw-14456-
dc.identifier.pmid29534228de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1117de_CH
zhaw.pages.start1106de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume47de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Accordini, S., Calciano, L., Johannessen, A., Portas, L., Benediktsdóttir, B., Bertelsen, R. J., Bråbäck, L., Carsin, A.-E., Dharmage, S. C., Dratva, J., Forsberg, B., Gomez Real, F., Heinrich, J., Holloway, J. W., Holm, M., Janson, C., Jögi, R., Leynaert, B., Malinovschi, A., et al. (2018). A three-generation study on the association of tobacco smoking with asthma. International Journal of Epidemiology, 47(4), 1106–1117. https://doi.org/10.1093/ije/dyy031
Accordini, S. et al. (2018) ‘A three-generation study on the association of tobacco smoking with asthma’, International Journal of Epidemiology, 47(4), pp. 1106–1117. Available at: https://doi.org/10.1093/ije/dyy031.
S. Accordini et al., “A three-generation study on the association of tobacco smoking with asthma,” International Journal of Epidemiology, vol. 47, no. 4, pp. 1106–1117, 2018, doi: 10.1093/ije/dyy031.
ACCORDINI, Simone, Lucia CALCIANO, Ane JOHANNESSEN, Laura PORTAS, Bryndis BENEDIKTSDÓTTIR, Randi Jacobsen BERTELSEN, Lennart BRÅBÄCK, Anne-Elie CARSIN, Shyamali C DHARMAGE, Julia DRATVA, Bertil FORSBERG, Francisco GOMEZ REAL, Joachim HEINRICH, John W HOLLOWAY, Mathias HOLM, Christer JANSON, Rain JÖGI, Bénédicte LEYNAERT, Andrei MALINOVSCHI, Alessandro MARCON, Jesús MARTÍNEZ-MORATALLA ROVIRA, Chantal RAHERISON, José Luis SÁNCHEZ-RAMOS, Vivi SCHLÜNSSEN, Roberto BONO, Angelo G CORSICO, Pascal DEMOLY, Sandra DORADO ARENAS, Dennis NOWAK, Isabelle PIN, Joost WEYLER, Deborah JARVIS und Cecilie SVANES, 2018. A three-generation study on the association of tobacco smoking with asthma. International Journal of Epidemiology. 2018. Bd. 47, Nr. 4, S. 1106–1117. DOI 10.1093/ije/dyy031
Accordini, Simone, Lucia Calciano, Ane Johannessen, Laura Portas, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, et al. 2018. “A Three-Generation Study on the Association of Tobacco Smoking with Asthma.” International Journal of Epidemiology 47 (4): 1106–17. https://doi.org/10.1093/ije/dyy031.
Accordini, Simone, et al. “A Three-Generation Study on the Association of Tobacco Smoking with Asthma.” International Journal of Epidemiology, vol. 47, no. 4, 2018, pp. 1106–17, https://doi.org/10.1093/ije/dyy031.


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