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https://doi.org/10.21256/zhaw-4872| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations |
| Autor/-in: | Bumbak, Fabian Cook, Stella Zachleder, Vilém Hauser, Silas Kovar, Karin |
| DOI: | 10.21256/zhaw-4872 10.1007/s00253-011-3311-6 |
| Erschienen in: | Applied Microbiology and Biotechnology |
| Band(Heft): | 91 |
| Heft: | 31 |
| Seite(n): | 31 |
| Seiten bis: | 46 |
| Erscheinungsdatum: | 2011 |
| Verlag / Hrsg. Institution: | Springer |
| ISSN: | 0175-7598 1432-0614 |
| Sprache: | Englisch |
| Schlagwörter: | Biomass; Biotechnology; Cell Culture Techniques; Culture Media; Microalgae |
| Fachgebiet (DDC): | 570: Biologie |
| Zusammenfassung: | Microalgae of numerous heterotrophic genera (obligate or facultative) exhibit considerable metabolic versatility and flexibility but are currently underexploited in the biotechnological manufacturing of known plant-derived compounds, novel high-value biomolecules or enriched biomass. Highly efficient production of microalgal biomass without the need for light is now feasible in inexpensive, well-defined mineral medium, typically supplemented with glucose. Cell densities of more than 100 g l(-1) cell dry weight have been achieved with Chlorella, Crypthecodinium and Galdieria species while controlling the addition of organic sources of carbon and energy in fedbatch mode. The ability of microalgae to adapt their metabolism to varying culture conditions provides opportunities to modify, control and thereby maximise the formation of targeted compounds with non-recombinant microalgae. This review outlines the critical aspects of cultivation technology and current best practices in the heterotrophic high-cell-density cultivation of microalgae. The primary topics include (1) the characteristics of microalgae that make them suitable for heterotrophic cultivation, (2) the appropriate chemical composition of mineral growth media, (3) the different strategies for fedbatch cultivations and (4) the principles behind the customisation of biomass composition. The review confirms that, although fundamental knowledge is now available, the development of efficient, economically feasible large-scale bioprocesses remains an obstacle to the commercialisation of this promising technology. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/12906 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY-NC 4.0: Namensnennung - Nicht kommerziell 4.0 International |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Lebensmittel- und Getränkeinnovation (ILGI) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| Bumbak2011_Article_BestPracticesInHeterotrophicHi.pdf | 1.08 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Bumbak, F., Cook, S., Zachleder, V., Hauser, S., & Kovar, K. (2011). Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations. Applied Microbiology and Biotechnology, 91(31), 31–46. https://doi.org/10.21256/zhaw-4872
Bumbak, F. et al. (2011) ‘Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations’, Applied Microbiology and Biotechnology, 91(31), pp. 31–46. Available at: https://doi.org/10.21256/zhaw-4872.
F. Bumbak, S. Cook, V. Zachleder, S. Hauser, and K. Kovar, “Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations,” Applied Microbiology and Biotechnology, vol. 91, no. 31, pp. 31–46, 2011, doi: 10.21256/zhaw-4872.
BUMBAK, Fabian, Stella COOK, Vilém ZACHLEDER, Silas HAUSER und Karin KOVAR, 2011. Best practices in heterotrophic high-cell-density microalgal processes : achievements, potential and possible limitations. Applied Microbiology and Biotechnology. 2011. Bd. 91, Nr. 31, S. 31–46. DOI 10.21256/zhaw-4872
Bumbak, Fabian, Stella Cook, Vilém Zachleder, Silas Hauser, and Karin Kovar. 2011. “Best Practices in Heterotrophic High-Cell-Density Microalgal Processes : Achievements, Potential and Possible Limitations.” Applied Microbiology and Biotechnology 91 (31): 31–46. https://doi.org/10.21256/zhaw-4872.
Bumbak, Fabian, et al. “Best Practices in Heterotrophic High-Cell-Density Microalgal Processes : Achievements, Potential and Possible Limitations.” Applied Microbiology and Biotechnology, vol. 91, no. 31, 2011, pp. 31–46, https://doi.org/10.21256/zhaw-4872.
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