Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
https://doi.org/10.21256/zhaw-4760| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Open peer review |
| Titel: | Statistically significant antidepressant-placebo differences on subjective symptom-rating scales do not prove that the drugs work : effect Size and method bias matter! |
| Autor/-in: | Hengartner, Michael P. Plöderl, Martin |
| DOI: | 10.21256/zhaw-4760 10.3389/fpsyt.2018.00517 |
| Erschienen in: | Frontiers in Psychiatry |
| Band(Heft): | 9 |
| Heft: | 517 |
| Erscheinungsdatum: | 2018 |
| Verlag / Hrsg. Institution: | Frontiers Research Foundation |
| ISSN: | 1664-0640 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 616.8: Neurologie und Krankheiten des Nervensystems |
| Zusammenfassung: | Following the publication of a recent meta-analysis by Cipriani et al., various opinion leaders and news reports claimed that the effectiveness of antidepressants has been definitely proven. E.g., Dr. Pariante, spokesperson for the Royal College of Psychiatrists, stated that this study “finally puts to bed the controversy on antidepressants, clearly showing that these drugs do work in lifting mood and helping most people with depression” (https://www.theguardian.com/science/2018/feb/21/the-drugs-do-work-antidepressants-are-effective-study-shows). We surely would embrace drug treatments that effectively help most people with depression, but based on work that has contested the validity of mostly industry-sponsored antidepressant trials we remain skeptical about antidepressants' clinical benefits. The most recent meta-analysis indeed concludes that antidepressants are more effective than placebo but also acknowledges that risk of bias was substantial and that the mean effect size of d = 0.3 was modest. Unfortunately, no clarification is given what this effect size means and whether it can be expected to be clinically significant in real-world routine practice. In this opinion paper we therefore ponder over how the reported effect size of d = 0.3 relates to clinical significance and how method bias undermines its validity, in order that the public, clinicians, and patients can judge for themselves whether antidepressants clearly work in most people with depression. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/12240 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Angewandte Psychologie |
| Organisationseinheit: | Psychologisches Institut (PI) |
| Enthalten in den Sammlungen: | Publikationen Angewandte Psychologie |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| Comment on Cipriani et al.pdf | Hengartner & Plöderl 2018 | 487.69 kB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Hengartner, M. P., & Plöderl, M. (2018). Statistically significant antidepressant-placebo differences on subjective symptom-rating scales do not prove that the drugs work : effect Size and method bias matter! Frontiers in Psychiatry, 9(517). https://doi.org/10.21256/zhaw-4760
Hengartner, M.P. and Plöderl, M. (2018) ‘Statistically significant antidepressant-placebo differences on subjective symptom-rating scales do not prove that the drugs work : effect Size and method bias matter!’, Frontiers in Psychiatry, 9(517). Available at: https://doi.org/10.21256/zhaw-4760.
M. P. Hengartner and M. Plöderl, “Statistically significant antidepressant-placebo differences on subjective symptom-rating scales do not prove that the drugs work : effect Size and method bias matter!,” Frontiers in Psychiatry, vol. 9, no. 517, 2018, doi: 10.21256/zhaw-4760.
HENGARTNER, Michael P. und Martin PLÖDERL, 2018. Statistically significant antidepressant-placebo differences on subjective symptom-rating scales do not prove that the drugs work : effect Size and method bias matter! Frontiers in Psychiatry. 2018. Bd. 9, Nr. 517. DOI 10.21256/zhaw-4760
Hengartner, Michael P., and Martin Plöderl. 2018. “Statistically Significant Antidepressant-Placebo Differences on Subjective Symptom-Rating Scales Do Not Prove That the Drugs Work : Effect Size and Method Bias Matter!” Frontiers in Psychiatry 9 (517). https://doi.org/10.21256/zhaw-4760.
Hengartner, Michael P., and Martin Plöderl. “Statistically Significant Antidepressant-Placebo Differences on Subjective Symptom-Rating Scales Do Not Prove That the Drugs Work : Effect Size and Method Bias Matter!” Frontiers in Psychiatry, vol. 9, no. 517, 2018, https://doi.org/10.21256/zhaw-4760.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.