|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Suppressing the morning rise in cortisol impairs free recall|
|Published in:||Learning & Memory|
|Publisher / Ed. Institution:||Cold Spring Harbor Laboratory Press|
|Subjects:||Adolescent; Circadian rhythm; Cross-over study; Double-blind method; Emotion; Enzyme inhibitor; Human; Hydrocortisone; Male; Memory disorder; Mental recall; Metyrapone; Neuropsychological test; Photic stimulation; Young adult|
|Subject (DDC):||610: Medicine and health|
|Abstract:||Elevated glucocorticoid levels impair memory retrieval. We investigated whether retrieval under naturally elevated glucocorticoid levels, i.e., during the morning rise in cortisol can be improved by suppressing cortisol. In a crossover study 16 men retrieved emotional and neutral texts and pictures (learned 3 d earlier) 30 min after morning awakening, following administration of the cortisol synthesis inhibitor metyrapone or placebo. Unexpectedly, the metyrapone-induced cortisol suppression significantly impaired free recall of both materials. Recognition remained unaffected. Thus, not only high, but also very low glucocorticoid levels impair retrieval, with the latter effect possibly reflecting insufficient occupation of hippocampal/amygdalar mineralocorticoid receptors (MRs).|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||School of Management and Law|
|Organisational Unit:||Winterthur Institute of Health Economics (WIG)|
|Appears in collections:||Publikationen School of Management and Law|
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